Bioactive Phenolic Constituents from the Seeds of Pharbitis nil
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概要
- 論文の詳細を見る
Two new lignans, termed pharsyringaresinol (1) and pharbilignoside (2), a new phenylethanoid glycoside, termed pharbiniloside (3), and 22 known compounds, were isolated from the ethanol extract of the seeds of Pharbitis nil. The structures of the new compounds (1—3) were determined on the basis of spectroscopic analyses, including 2D-NMR and circular dichroism (CD) spectroscopy studies. Among the isolates, compounds 2, 11, 12, and 24 exhibited significant cytotoxicity against human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) with IC50 values ranging from 8.07 to 28.30 μM. In addition, compounds 11, 12 and 24 potently inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells, a microglia cells with IC50 values ranging from 14.7 to 19.9 μM.
- 公益社団法人 日本薬学会の論文
著者
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Lee Kang
Natural Products Lab. Coll. Of Pharmacy Sungkyunkwan Univ.
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Ha Sang
Graduate School Of East-west Medical Science Kyung Hee University
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Kim Ki
Natural Products Lab. School Of Pharmacy Sungkyunkwan Univ.
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Choi Sang
Korea Food Res. Inst.
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Kim Sun
Graduate School Of East-west Medical Science East-west Integrated Medical Science Research Center Ky
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Kim Sun
Graduate School Of East-west Medical Science
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KIM Ki
Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University
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