Triterpene Saponins from Pleurospermum kamtschaticum and Their Biological Activity
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概要
- 論文の詳細を見る
Eleven new triterpene saponins (1–11), together with fourteen known triterpene and triterpene saponins (12–25) were isolated from a MeOH extract of Pleurospermum kamtschaticum HOFFMANN (Umbelliferae). The chemical structures of the new compounds (1–11) were determined by means of MS, 1H-NMR, 13C-NMR, correlated spectroscopy (COSY), heteronuclear multiple bond correlation (HMBC), total correlated spectroscopy (TOCSY) and nuclear Overhauser effect spectroscopy (NOESY) to be pleurosaponin A (1)–K (11). The isolated compounds were tested for their cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, HCT15) in vitro using the sulforhodamine B bioassay (SRB) assay. All compounds showed little cytotoxicity against tested cell lines (IC50 >30 µM).
著者
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Lee Kang
Natural Products Lab. Coll. Of Pharmacy Sungkyunkwan Univ.
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Choi Sang
Korea Food Res. Inst.
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Lee Il
Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University
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LEE Kang
Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University
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