Anti-ulcerogenic Effect and HPLC Analysis of the Caffeoylquinic Acid-Rich Extract from Ligularia stenocephala

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概要

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• The leaves of three Ligularia species belonging to the family Compositae, Ligularia stenocephala, L. fischeri, and L. fischeri var. spiciformis, were qualitatively and quantitatively analyzed on the caffeoylquinic acids by HPLC and subjected to peroxynitrite-scavenging assay. The IC50 of the MeOH extract of L. stenocephala was 1.62±0.03 μg/ml and the major caffeoylquinic acids of L. stenocephala were 5-O-caffeoylquinic acid, 3,5-di-O-caffeoyl-muco-quinic acid, and 3,5-di-O-caffeoylquinic acid. The compositions of caffeoylquinic acids were different for the three plants. Since percentage of total caffeoylquinic acids of the extract was highest (42.20% of the MeOH extract and 94.52% of the BuOH extract) in L. stenocephala and potent in peroxynitrite-scavenging assay, the extracts of L. stenocephala were chosen to perform in vivo anti-ulcerogenic activity. Treatment of mice with the MeOH- and BuOH extracts decreased the diameter of gastric lesions caused by HCl/ethanol- and indomethacin/bethanechol and decreased the volume of gastric juice, suggesting that caffeoylquinic acids have anti-ulcerogenic activity. These results suggest that the leaves of Ligularia species may help prevent or treat gastric ulcers.

• 公益社団法人　日本薬学会の論文

著者

• Lee Kyung-tae

  College Of Pharmacy Kyung-hee University

• Park Hee-juhn

  Department Of Botanical Resources Sangi University

• Kim Won-bae

  Highland Agriculture Res. Center Rural Dev. Administration

• CHOI Jongwon

  College of Pharmacy, Kyungsung University

• Lee Kang

  Natural Products Lab. Coll. Of Pharmacy Sungkyunkwan Univ.

• Choi Jae

  Division of Food Science and Biotechnology, Pukyong National University

• Choi Jongwon

  College Of Pharmacy Daeyeon-dong Kyungsung University

• Nugroho Agung

  Department of Pharmacology, Informational Biomedicine, Ehime University Graduate School of Medicine

• Lee Byung-Il

  Department of Food Science and Biotechnology, Kangwon National University

• Bachri Moch

  College of Pharmacy, Kyungsung University

• Lee Jong-Dai

  Department of Food Science and Biotechnology, Kangwon National University

• Choi Jae

  Division Of Food Science And Biotechnology Pukyong National University

• Kim Won-Bae

  Highland Agriculture Research Center, Rural Development Administration

• Lee Kang

  Natural Products Laboratory, College of Pharmacy, SungKyunKwan University

• Nugroho Agung

  Department of Agro-industrial Technology, Faculty of Agriculture, Lambung Mangkurat University

• Choi Jae

  Division of Cardiology, Department of Internal Medicine, Kangnam St. Mary's Hospital, The Catholic University of Korea

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