Identification of a New Naphthalene and Its Derivatives from the Bulb of Eleutherine americana with Inhibitory Activity on Lipopolysaccharide-Induced Nitric Oxide Production
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概要
- 論文の詳細を見る
A new naphthoquinone, (-)-3-[2-(acetyloxy)propyl]-2-hydroxy-8-methoxy-1, 4-naphthoquinone (1) was isolated from the bulb of Eleutherine americana MERR. et HEYNE (Iridaceae) together with two known compounds, eleutherinol (6) and 1, 5-dihydroxy-3-methylanthraquinone (7) which were found in this species for the first time. The other known compounds, (-)-isoeleutherin (2), (+)-eleutherin (3), (-)-hongconin (4), and (+)-dihydroeleutherinol (5) which were reported previously from this species, were also isolated in the present study. Compounds 2-6 exhibited potent inhibitory activity on nitric oxide production in RAW 264.7 lipopolysaccharide-activated mouse macrophage cells with IC_<50> values of 7.7, 11.4, 19.8, 21.7, and 34.4μM, respectively, whereasthe other two compounds, 1 and 7, were inactive. The structure of compound 1 was elucidated by spectroscopic data analysis including 1D and 2D NMR experiments.
- 社団法人日本薬学会の論文
- 2008-09-01
著者
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Lee Sang
College Of Industrial Science Chung-ang University
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Lee Kang
Natural Products Lab. Coll. Of Pharmacy Sungkyunkwan Univ.
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Han Ah-reum
韓国
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Han Ah-reum
College Of Pharmacy And Center For Cell Signaling & Drug Discovery Research Ewha Womans Universi
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Lee Sang
Coll. Of Pharmacy Ewha Womans Univ.
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LEE Na-Youn
College of Pharmacy and The Center for Cell Signaling & Drug Discovery Research, Ewha Womans Univers
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MIN Hye-Young
College of Pharmacy and The Center for Cell Signaling & Drug Discovery Research, Ewha Womans Univers
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NAM Joo-Won
College of Pharmacy and The Center for Cell Signaling & Drug Discovery Research, Ewha Womans Univers
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SUPRAPTO Wahyu
Batu Herba Medica Centre
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SEO Eun-Kyoung
College of Pharmacy and The Center for Cell Signaling & Drug Discovery Research, Ewha Womans Univers
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WIRYAWAN Adam
Faculty of Sciences, Brawijaya University
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LEE Kang
College of Pharmacy, Sungkyunkwan University
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Min Hye
College Of Pharmacy And The Center For Cell Signaling & Drug Discovery Research Ewha Womans Univ
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Lee Na-youn
College Of Pharmacy And The Center For Cell Signaling & Drug Discovery Research Ewha Womans Univ
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Wiryawan Adam
Faculty Of Sciences Brawijaya University
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Lee Kang
College Of Pharmacy Sungkyunkwan University
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Nam Joo-won
Coll. Of Pharmacy Ewha Womans Univ.
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Seo Eun-kyoung
Natural Product Chemistry Laboratory College Of Pharmacy And The Center For Cell Signaling & Dru
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Seo Eun
Natural Product Chemistry Laboratory College Of Pharmacy & The Center For Cell Signaling And Dru
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Lee Sang
College Of Agriculture And Life Sciences Kyungpook National University
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Han Ah-reum
Dep. Of Physiology Coll. Of Oriental Medicine Kyung Hee Univ.
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