Protective Effects of Quinic Acid Derivatives on Tetranydropapaveroline-Induced Cell Death in C6 Glioma Cells
スポンサーリンク
概要
- 論文の詳細を見る
Protective effects of quinic acids from Aster scaber on tetrahydropapaveroline (THP) -induced cell toxicity were evaluated in rat C6 glioma cells. Among 4 quinic acid derivatives tested, (-) 4,5-dicaffeoyl quinic acid (QA3) exhibited the highest protective effect against THP-induced cell toxicity. C6 cells treated with THP exhibited the decrease in the survival rate and activities of glutathione peroxidasc and catalase, but increased the level of malondialdehyde and superoxide dismutase activity. Staining C6 cells with propidium iodide and Hoechst 33342 revealed that 10 μM of THP treatment caused to necrotic and apoptotic cell death. However, preincubation of cells with QA3 prior to THP exposure recovered the cell survival rate and activities of antioxidant enzymes to control level. Taken together, the results indicate that QA3 might be a potential agent for treating or preventing diseases with oxidative stress.
- 社団法人日本薬学会の論文
- 2003-06-01
著者
-
SOH Yunjo
Department of Dental Pharmacology, School of Dentistry, Chonbuk National University
-
Lee Kang
Natural Products Laboratory College Of Pharmacy Sung Kyun Kwan University
-
Sohn Won
Department Of Electronics And Radio Engineering Kyung Hee University
-
Sohn Won
Department Of Neuroscience Graduate School Of East-west Medical Science Kyung Hee University
-
Sohn Nak
Department Of Neuroscience Graduate School Of East-west Medical Science Kyung Hee University
-
LEE Kang
College of Pharmacy, Sungkyunkwan University
-
Kim J‐a
Yeungnam Univ. Gyeongsan Kor
-
KiM Ji-Ae
Department of Neuroscience, Graduate School of East-West Medical Science, Kyung Hee University
-
KIM Yeou
Department of Oriental Pharmacology, Graduate School of East- West Medical Science, Kyung Hee Univer
-
Lee Kang
College Of Pharmacy Sungkyunkwan University
-
Kim Yeou
Department Of Oriental Pharmacology Graduate School Of East- West Medical Science Kyung Hee Universi
-
Soh Yunjo
Department Of Neuroscience Graduate School Of East-west Medical Science Kyung Hee University
-
Soh Yunjo
Department Of Biological Sciences Auburn University
関連論文
- Protective Effects of Cinnamomum cassia Blume in the Fibrogenesis of Activated HSC-T6 Cells and Dimethylnitrosamine-Induced Acute Liver Injury in SD Rats
- Synchronizing schemes for SVC layered signals of satellite broadcasting system using independent RF channels (衛生通信)
- Synchronizing Schemes for SVC Layered Signals of Satellite Broadcasting System Using Independent RF Channels
- Identification of a New Naphthalene and Its Derivatives from the Bulb of Eleutherine americana with Inhibitory Activity on Lipopolysaccharide-Induced Nitric Oxide Production
- Protective Effects of Quinic Acid Derivatives on Tetranydropapaveroline-Induced Cell Death in C6 Glioma Cells
- Determination of growth hormone-releasing hexapeptide by reversed-phase high-performance liquid chromatography with electrochemical detection
- Microbore high-performance liquid chromatographic determination of cisapride in rat serum samples using column switching
- Immobilization of Arg-Gly-Asp (RGD) Sequence in Sugar Containing Copolymer for Culturing of Pheochromocytoma (PC12) Cells (MEDICAL BIOTECHNOLOGY)
- Pharmacokinetic Disposition of Polyethylene Glycol-Modified Salmon Calcitonins in Rats
- Reversed-phase high-performance liquid chromatography of radioiodinated salmon calcitonins
- Reversed-phase high-performance liquid chromatography of salmon calcitonin and its degradation products in biological samples using column switching and flow-through radioisotope detection
- A New Caffeoly Quinic Acid from Aster scaber and Its Inhibitory Activity against Human Immunodeficiency Virus-1 (HIV-1) Integrase
- New Cytotoxic Butanolides from Lindera obtusiloba BLUME
- A Link Analysis for the Ka band Satellite Broadcasting Service in Korea(Satellite System I)
- Neuroprotective and Neurotrophic Effects of Quinic Acids from Aster scaber in PC12 Cells
- Two New Monoterpene Peroxide Glycosides from Aster scaber
- Protective Effects of Cuscutae semen against Dimethylnitrosamine-Induced Acute Liver Injury in Sprague-Dawley Rats(Pharmacology)
- Nasal Absorption and Pharmacokinetic Disposition of Salmon Calcitonin Modified with Low Molecular Weight Polyethylene Glycol
- Identification of the modifying sites of mono-PEGylated salmon calcitonins by capillary electrophoresis and MALDI-TOF mass spectrometry
- Absorption, First-Pass Metabolism, and Disposition of Itraconazole in Rats
- Protective Effects of Cinnamomum cassia Blume in the Fibrogenesis of Activated HSC-T6 Cells and Dimethylnitrosamine-Induced Acute Liver Injury in SD Rats
- Lithospermi radix Extract Inhibits Histamine Release and Production of Inflammatory Cytokine in Mast Cells
- Development and validation of a reversed-phase fluorescence HPLC method for determination of bucillamine in human plasma using pre-column derivatization with monobromobimane
- Determination of metoclopramide in human plasma using hydrophilic interaction chromatography with tandem mass spectrometry
- Purification and Characterization of a Novel Protamine Kinase in HL60 Cells
- Low Molecular Weight (1 kDa) Polyethylene Glycol Conjugation Markedly Enhances the Hypoglycemic Effects of Intranasally Administered Exendin-4 in Type 2 Diabetic db/db Mice