A New Caffeoly Quinic Acid from Aster scaber and Its Inhibitory Activity against Human Immunodeficiency Virus-1 (HIV-1) Integrase
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概要
- 論文の詳細を見る
The phytochemical study of the aerial parts of Aster scaber THUNB. (Asteraceae) yielded a new caffeoyl quinic acid, (-) 3,5-dicaffeoyl-muco-quinic acid (2) and three known compounds, (-) 3,5-dicaffeoyl quinic acid (1), (-) 4,5-dicaffeoyl quinic acid (3), (-) 5-caffeoyl quinic acid (4). The structures were established by high resolution spectroscopic methods. The antiviral effects against HIV-1 integrase of the compounds was evaluated. (-) 3,5-Dicaffeoyl-muco-quinic acid (2) exhibited potent antiviral activity with an IC_<50> value of 7.0±1.3 μg/ml.
- 公益社団法人日本薬学会の論文
- 2000-11-01
著者
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Kim S
Kyung Hee Univ. Seoul Kor
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Kim Sun
Department Of Chemical Engineering Sogang University
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Choi Sang
Research Institute Of Chemical Technology
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Choi Sang
Korea Research Institute Of Chemical Technology
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Lee Kang
Natural Products Lab. Coll. Of Pharmacy Sungkyunkwan Univ.
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Lee Jong
Research Institute of Environmental Medicine, Nagoya University
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Lee Kang
Natural Products Laboratory College Of Pharmacy Sung Kyun Kwan University
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Kwon Hak
Natural Products Laboratory College Of Pharmacy Sung Kyun Kwan University
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LEE Kang
College of Pharmacy, Sungkyunkwan University
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Kim Sun
Graduate School Of East-west Medical Science Kyung Hee University
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Jung Chil
Natural Products Laboratory College Of Pharmacy Sung Kyun Kwan University
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Kim H
Neitmtoxicology Program. Department Of Pharmacy Kangwon National University
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Lee Kang
College Of Pharmacy Sungkyunkwan University
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SHIN Cha
Department of Biotechnology, Chung Ang University
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Kwon Hak
Graduate School Of East-west Medical Science Kyung Hee University
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Shin Cha
Department Of Biotechnology Chung Ang University
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Kim S
Graduate School Of East-west Medical Science Kyung Hee University
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Lee Jong
Research Institute Of Chemical Technology
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Kim Sun
Department Of Applied Chemistry Faculty Of Engineering Osaka University
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Kim Sun
East-west Integrated Medical Sci. Res. Center Kyung Hee Univ.
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Kim Sun
Department Of Animal Science And Technology Seoul National University
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Kwon Hak
Natural Medicine Center, Korea Institute of Science and Technology (KIST), Gangneung
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