Effects of Paeonia radix on 5-Hydroxytryptamine Synthesis and Tryptophan Hydroxylase Expression in the Dorsal Raphe of Exercised Rats

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概要

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• Paeonia radix is the root of Paeonia japonica MIYABE, a perennial plant classified in the family Paeoniaceae. In the present study, the effects of Paeonia radix on performance in treadmill exercise, and 5-hydroxytryptamine (5-HT) synthesis and tryptophan hydroxylase (TPH) expression in the dorsal raphe were investigated. Time to exhaustion in treadmill exercise was increased and exercise-induced increases in 5-HT synthesis and TPH expression in the dorsal raphe were shown to be suppressed by Paeonia radix treatment; 5-HT synthesis and TPH expression were inhibited by Paeonia radix treatment under resting conditions as well. In sum, treatment with Paeonia radix, inhibiting 5-HT synthesis and TPH expression, may bring about reduced fatigue, both during exercise and the resting state.

• 社団法人日本薬学会の論文
• 2003-02-01

著者

• KIM Sung-Soo

  Department of Internal Medicine, Chonnam National University Hospital

• Kim C‐j

  Department Of Physiology College Of Medicine Kyung Hee University

• Kim C‐j

  Kyung Hee Univ. Seoul Kor

• LEE Taeck-Hyun

  Department of Physiology, College of Medicine, Kyung Hee University

• JANG Mi-Hyeon

  Department of Physiology, College of Medicine, Kyung Hee University

• KIM Hong

  Department of Physiology, College of Medicine, Kyung Hee University

• KIM Chang-Ju

  Department of Physiology, College of Medicine, Kyung Hee University

• CHUNG Seok-Hee

  Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung Hee University

• LEE Jong-Soo

  Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung Hee University

• SHIN Hyun-Dae

  Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung Hee University

• LIM Baek-Vin

  Department of Physiology, College of Medicine, Kyung Hee University

• HONG Jung-Ae

  Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung Hee University

• KIM Young-Pyo

  Department of Sports and Leisure Studies, Hannam University

• Lee Jong-soo

  Department Of Physiology College Of Medicine Kyung Hee University

• Lee Jong-soo

  Department Of Electrical Engineering And Institute For Nano Science Korea University

• Lee J‐s

  Department Of Physiology College Of Medicine Kyung Hee University

• Shin H‐d

  College Of Nursing Science Kyung Hee University

• Kim Sung-soo

  Department Of Oriental Rehabilitation Medicine College Of Oriental Medicine Kyung Hee University

• Kim Sung-soo

  Department Of Applied Chemistry Graduate School Of Science And Engineering Tokyo Institute Of Techno

• Kim H

  Department Of Oriental Sports Medicine College Of Health & Therapy Daegu Haany University

• Lee T‐h

  Department Of Physiology College Of Medicine Kyung Hee University

• Lee Taeck-hyun

  韓国

• Lee Jong-sung

  Biotoxtech Co. Ltd.

• Lee Jong-sung

  韓国

• Lee J‐d

  Department Of Microbiology College Of Natural Sciences Pusan National University

• Kim S

  Graduate School Of East-west Medicine Kyung Hee Univ.

• Jang M‐h

  Department Of Physiology College Of Medicine Kyung Hee University

• Kim Sun

  Graduate School Of East-west Medical Science Kyung Hee University

• Lee Jun

  Department Of Pharmacy College Of Pharmacy Pusan National University

• Kim Y

  Department Of Physiology College Of Medicine Kyung Hee University

• Kim Y‐s

  Seoul National Univ. Seoul Kor

• Chung Seok-hee

  Department Of Oriental Rehabilitation Medicine College Of Oriental Medicine Kyung Hee University

• Lim Baek-vin

  Department Of Physiology College Of Medicine Kyung Hee University

• Jang Mi-hyeon

  Department Of Physiology College Of Medicine Kyung Hee University

• Kim Chang-ju

  Department Of Physiology College Of Medicine Kyung Hee University

• Kim Y‐j

  Chung‐ang Univ. Seoul Kor

• Kim Hong

  Department Of Oriental Sports Medicine College Of Health & Therapy Daegu Haany University

• Lee Jun-sik

  Department Of Microbiology College Of Natural Sciences Pusan National University

• Lee Taeck-hyun

  Department Of Physiology College Of Medicine Kyung Hee University

• Kim Young-pyo

  Department Of Physiology College Of Medicine Kyung Hee University

• Lee J

  Kyung Hee Univ. Seoul Kor

• Kim Chang-ju

  Dep. Of Physiology Kyung Hee Univ.

• Kim Hong

  Department Of Chemistry Advanced Materials Chemistry Research Center Korea University

• Hong Jung-ae

  Department Of Oriental Rehabilitation Medicine College Of Oriental Medicine Kyung Hee University

• Lee J

  Research Group Of Pain And Neuroscience In Vision 2000 Project East-west Medical Research Institute

• Kim H

  Graduate School Of East-west Medical Science Kyung Hee University

• Kim Sun

  East-west Integrated Medical Sci. Res. Center Kyung Hee Univ.

• Kim Hong

  Department of Applied Sciences, Korea Maritime University, Busan 606-791, Korea

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