Maternal Alcohol Administration Suppresses Expression of Nitric Oxide Synthase in the Hippocampus of Offspring Rats

元データ 2005-08-20 社団法人 日本薬理学会

概要

Maternal alcohol consumption during pregnancy can produce teratogenic effects and has a detrimental effect on the development of the fetus. In this study, the dose-dependent effect of maternal alcohol administration on the expression of nitric oxide synthase (NOS) in the hippocampus of the offspring rats was investigated. From the present result, it was shown that expression of NOS is decreased following treatment with maternal alcohol in a dose-dependent fashion. The present results suggest that suppression of NOS expression in the hippocampus of offspring rats with maternal alcohol mediates the associated developmental retardation and/or anomalies.

著者

Kim C‐j Department Of Physiology College Of Medicine Kyung Hee University
Kim C‐j Kyung Hee Univ. Seoul Kor
KIM Eun-Kyung College of Medicine, Kohwang Medical Research Institute, Kyung Hee University
JANG Mi-Hyeon Department of Physiology, College of Medicine, Kyung Hee University
LEE Myoung-Hwa Department of Physiology, College of Medicine, Kyung Hee University
KIM Hong Department of Physiology, College of Medicine, Kyung Hee University
LEE Sam-Jun Department of Physiology, College of Medicine, Kyung Hee University
SIM Young-Je Department of Physiology, College of Medicine, Kyung Hee University
KIM Chang-Ju Department of Physiology, College of Medicine, Kyung Hee University
PARK Se-Keun Department of Food & Nutrition in Oriental Medicine, Semyung University
KIM Jeongseon Department of Food & Nutrition in Oriental Medicine, Semyung University
KIM Ee-Hwa Department of Acupoint & Meridian, College of Oriental Medicine, Semyung University
Lee Sam-jun 韓国
Lee Sam-jun Department Of Sports And Leisure Studies College Of Social Sciences Tongmyong University
Kim Chang-ju 韓国
Kim Ee-hwa Department Of Physiology College Of Medicine Kyung Hee University
Kim Ee-hwa 韓国
Kim H Department Of Oriental Sports Medicine College Of Health & Therapy Daegu Haany University
Lee M‐h Department Of Physiology College Of Medicine Kyung Hee University
Yim Sung-vin 韓国
Lee Myoung-hwa Department Of Physiology College Of Medicine Kyung Hee University
Jang M‐h Department Of Physiology College Of Medicine Kyung Hee University
Park Sung-ho Department Of Food & Nutrition In Oriental Medicine Semyung University
Jang Mi-hyeon Department Of Physiology College Of Medicine Kyung Hee University
Kim Chang-ju Department Of Physiology College Of Medicine Kyung Hee University
Kim Hong Department Of Oriental Sports Medicine College Of Health & Therapy Daegu Haany University
Kim Chang-ju Dep. Of Physiology Kyung Hee Univ.
Kim Hong Department Of Chemistry Advanced Materials Chemistry Research Center Korea University
Sim Young-je Department Of Physiology College Of Medicine Kyung Hee University
Kim H Graduate School Of East-west Medical Science Kyung Hee University
Sim Young-je Department Of Pharmacology School Of Medicine Kyung Hee University
Kim Hong Department of Applied Sciences, Korea Maritime University, Busan 606-791, Korea

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