Armeniacae semen Extract Suppresses Lipopolysaccharide-Induced Expressions of Cycloosygenase-2 and Inducible Nitric Oxide Synthase in Mouse BV2 Microglial Cells(Pharmacology)

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概要

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• Armeniacae semen is the seed of Prunus armeniaca L. var. ansu MAXIM which is classified into Rosaceae. In traditional oriental medicine, Armeniacae semen has been used for the treatment of pain and inflammatory diseases. In this study, the effect of Armeniacae semen extract on lipopolysaccharide-induced inflammation was investigated using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay, reverse transcription-polymerase chain reaction (RT-PCR), Western blot, prostaglandin E_2 immunoassay, and nitric oxide detection on mouse BV2 microglial cells. In the present results, Armeniacae semen extract suppressed prostaglandin E_2 synthesis and nitric oxide production by inhibiting the lipopolysaccharide-stimulated enhancement of cyclooxygenase-2 and inducible nitric oxide synthase mRNA expression in BV2 cells. These results show that Armeniacae semen exerts anti-inflammatory and analgesic effects probably by suppression of cyclooxygenase-2 and inducible nitric oxide synthase expressions.

• 公益社団法人日本薬学会の論文
• 2005-03-01

著者

• Lee Myoung

  Department of Internal Medicine, Seoul National University College of Medicine, Cardiovascular Labor

• Kim C‐j

  Department Of Physiology College Of Medicine Kyung Hee University

• Kim C‐j

  Kyung Hee Univ. Seoul Kor

• YANG Hye-Young

  Department of Physiology, College of Medicine, Kyung Hee University

• CHANG Hyun-Kyung

  Department of Physiology, College of Medicine, Kyung Hee University

• LEE Taeck-Hyun

  Department of Physiology, College of Medicine, Kyung Hee University

• SHIN Min-Chul

  Department of Physiology, College of Medicine, Kyung Hee University

• LEE Myoung-Hwa

  Department of Physiology, College of Medicine, Kyung Hee University

• Kim Chang-ju

  韓国

• Shin Min

  Departments Of Preventive Medicine Chonnam National University Medical School

• Lee T‐h

  Department Of Physiology College Of Medicine Kyung Hee University

• Lee Taeck-hyun

  韓国

• Lee M‐h

  Department Of Physiology College Of Medicine Kyung Hee University

• KIM Chang

  Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine

• Shin M‐c

  Department Of Physiology College Of Medicine Kyung Hee University

• Chang H‐k

  Department Of Physiology College Of Medicine Kyung Hee University

• Kim Ok

  Department of Obstetrics and Gynecology of Catholic University of Korea

• CHO Sonhae

  Department of Oriental Pharmaceutical Sciences, College of Pharmacy, Kyung Hee University

• Kim Chang-ju

  Department Of Physiology College Of Medicine Kyung Hee University

• CHANG Hyun

  Department of Physiology, College of Medicine, Kyung Hee University

• YANG Hye

  Department of Physiology, College of Medicine, Kyung Hee University

• LEE Taeck

  Department of Physiology, College of Medicine, Kyung Hee University

• SHIN Mal

  Department of Physiology, College of Medicine, Kyung Hee University

• HONG Seon

  Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University

• Kim Chang

  Department Of Ceramic Science And Engineering Korea Advanced Institute Of Science And Technology

• Lee Taeck-hyun

  Department Of Physiology College Of Medicine Kyung Hee University

• Kim Chang-ju

  Dep. Of Physiology Kyung Hee Univ.

• Lee Myoung

  Department Of Electrical And Electronic Engineering In Yonsei University

• Yang Hye-young

  Department Of Physiology College Of Medicine Kyung Hee University

• Hong Seon

  Department Of Oriental Pharmaceutical Science College Of Pharmacy Kyung Hee University

• Cho Sonhae

  Department Of Oriental Pharmaceutical Science College Of Pharmacy Kyung Hee University

• Kim Ok

  Department Of Oriental Pharmaceutical Science College Of Pharmacy Kyung Hee University

• Yang Hye

  Department Of Biomaterials Engineering Division Of Biotechnology And Bioengineering Kangwon National

• Kim Ok

  Department Of Environmental Engineering Anyang University Anyangshi

• Chang Hyun

  Department Of Physical Medicine And Rehabilitation Samsung Changwon Hospital Sungkyunkwan University

• Kim Chang

  Department Of Biochemistry University Of Oxford

• Shin Min

  Department Of Psychiatry Seoul National University College Of Medicine

• Shin Min

  Department of Applied Science, Korea Maritime University, Busan 606-791, Korea

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