Atractylodes japonica Suppresses Lipopolysaccharide-Stimulated Expressions of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 in RAW 264.7 Macrophages (Pharmacology)
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概要
- 論文の詳細を見る
Atractylodes japonica has traditionally been used for the treatment of pain and arthritis. The effect of Atractylodes japonica against lipopolysaccharide-induced inflammation was investigated using reverse transcription-polymerase chain reaction (RT-PCR), nitric oxide detection, and prostaglandin E_2 (PGE_2) immunoassay in mouse RAW 264.7 macrophages. The aqueous extract of Atractylodes japonica suppressed nitric oxide production and PGE_2 synthesis by inhibition of the lipopolysaccharide-stimulated enhancement of inducible nitric oxide synthase and cyclooxygenase-2 mRNAs expressions in RAW 264.7 macrophages. These results suggest that Atractylodes japonica exerts anti-inflammatory and analgesic effects probably by suppression of the inducible nitric oxide synthase and cyclooxyeenase-2 expressions.
- 社団法人日本薬学会の論文
- 2004-03-01
著者
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Kim C‐j
Department Of Physiology College Of Medicine Kyung Hee University
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Kim C‐j
Kyung Hee Univ. Seoul Kor
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KIM Eun-Kyung
College of Medicine, Kohwang Medical Research Institute, Kyung Hee University
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JANG Mi-Hyeon
Department of Physiology, College of Medicine, Kyung Hee University
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SHIN Min-Chul
Department of Physiology, College of Medicine, Kyung Hee University
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KIM Chang-Ju
Department of Physiology, College of Medicine, Kyung Hee University
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KIM Ee-Hwa
Department of Acupoint & Meridian, College of Oriental Medicine, Semyung University
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KIM Ye-Jin
Department of Physiology, College of Medicine, Kyung Hee University
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KIM Yeunhee
Department of Biochemistry, College of Oriental Medicine, Semyung University
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Kim Chang-ju
韓国
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Kim Ee-hwa
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Ee-hwa
韓国
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Jang M‐h
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Y
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Y‐s
Seoul National Univ. Seoul Kor
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Shin M‐c
Department Of Physiology College Of Medicine Kyung Hee University
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Shin Min-chul
Department Of Physiology College Of Medicine Kyung Hee University
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Jang Mi-hyeon
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Chang-ju
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Y‐j
Chung‐ang Univ. Seoul Kor
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Kim Chang-ju
Dep. Of Physiology Kyung Hee Univ.
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