Effects of Puerariae radix on Cell Proliferation and Nitric Oxide Synthase Expression in Dentate Gyrus of Alcohol-Intoxicated Sprague-Dawley Rats
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概要
- 論文の詳細を見る
Traditionally, Puerariae radix had been used for the treatment of alcohol-related problems. In this study, effects of Puerariae radix on cell proliferation and nitric oxide synthase expression in the dentate gyrus of alcohol-intoxicated Sprague-Dawley rats were investigated via 5-bromo-2-deoxyuridine (BrdU) immunohistochemistry and nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry. Alcohol administration was shown to inhibit the numbers of both BrdU-positive and NADPH-d-positive cells, while Puerariae radix treatment was shown to increase those numbers. It is possible that nitric oxide, which might play an important role in the regulation of cell proliferation, is a major target of the toxic effects of alcohol.
- 社団法人 日本薬理学会の論文
- 2002-03-01
著者
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Kim C‐j
Department Of Physiology College Of Medicine Kyung Hee University
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Kim C‐j
Kyung Hee Univ. Seoul Kor
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KIM Eun-Kyung
College of Medicine, Kohwang Medical Research Institute, Kyung Hee University
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JANG Mi-Hyeon
Department of Physiology, College of Medicine, Kyung Hee University
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SHIN Min-Chul
Department of Physiology, College of Medicine, Kyung Hee University
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KIM Chang-Ju
Department of Physiology, College of Medicine, Kyung Hee University
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KIM Ee-Hwa
Department of Acupoint & Meridian, College of Oriental Medicine, Semyung University
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KIM Yeunhee
Department of Biochemistry, College of Oriental Medicine, Semyung University
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SHIN Hyun-Dae
Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung Hee University
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CHUNG Joo-Ho
Departments of Pharmacology, College of Medicine, Kyung Hee University
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Chung J‐h
Departments Of Pharmacology College Of Medicine Kyung Hee University
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Kim Ee-hwa
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Ee-hwa
韓国
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Shin H‐d
College Of Nursing Science Kyung Hee University
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Jang M‐h
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Y
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Y‐s
Seoul National Univ. Seoul Kor
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Shin M‐c
Department Of Physiology College Of Medicine Kyung Hee University
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Shin Min-chul
Department Of Physiology College Of Medicine Kyung Hee University
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Chung Joo-ho
Departments Of Pharmacology College Of Medicine Kyung Hee University
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Chung Joo-ho
Department Of Pharmacology College Of Medicine Kohwang Medical Research Institute Kyung Hee Universi
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Jang Mi-hyeon
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Chang-ju
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Y‐j
Chung‐ang Univ. Seoul Kor
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Kim Chang-ju
Dep. Of Physiology Kyung Hee Univ.
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