Effects of Puerariae radix on Cell Proliferation and Nitric Oxide Synthase Expression in Dentate Gyrus of Alcohol-Intoxicated Sprague-Dawley Rats

元データ 2002-03-01 社団法人 日本薬理学会

概要

Traditionally, Puerariae radix had been used for the treatment of alcohol-related problems. In this study, effects of Puerariae radix on cell proliferation and nitric oxide synthase expression in the dentate gyrus of alcohol-intoxicated Sprague-Dawley rats were investigated via 5-bromo-2-deoxyuridine (BrdU) immunohistochemistry and nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry. Alcohol administration was shown to inhibit the numbers of both BrdU-positive and NADPH-d-positive cells, while Puerariae radix treatment was shown to increase those numbers. It is possible that nitric oxide, which might play an important role in the regulation of cell proliferation, is a major target of the toxic effects of alcohol.

著者

Kim C‐j Department Of Physiology College Of Medicine Kyung Hee University
Kim C‐j Kyung Hee Univ. Seoul Kor
KIM Eun-Kyung College of Medicine, Kohwang Medical Research Institute, Kyung Hee University
JANG Mi-Hyeon Department of Physiology, College of Medicine, Kyung Hee University
SHIN Min-Chul Department of Physiology, College of Medicine, Kyung Hee University
KIM Chang-Ju Department of Physiology, College of Medicine, Kyung Hee University
KIM Ee-Hwa Department of Acupoint & Meridian, College of Oriental Medicine, Semyung University
KIM Yeunhee Department of Biochemistry, College of Oriental Medicine, Semyung University
SHIN Hyun-Dae Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung Hee University
CHUNG Joo-Ho Departments of Pharmacology, College of Medicine, Kyung Hee University
Chung J‐h Departments Of Pharmacology College Of Medicine Kyung Hee University
Kim Ee-hwa Department Of Physiology College Of Medicine Kyung Hee University
Kim Ee-hwa 韓国
Shin H‐d College Of Nursing Science Kyung Hee University
Jang M‐h Department Of Physiology College Of Medicine Kyung Hee University
Kim Y Department Of Physiology College Of Medicine Kyung Hee University
Kim Y‐s Seoul National Univ. Seoul Kor
Shin M‐c Department Of Physiology College Of Medicine Kyung Hee University
Shin Min-chul Department Of Physiology College Of Medicine Kyung Hee University
Chung Joo-ho Departments Of Pharmacology College Of Medicine Kyung Hee University
Chung Joo-ho Department Of Pharmacology College Of Medicine Kohwang Medical Research Institute Kyung Hee Universi
Jang Mi-hyeon Department Of Physiology College Of Medicine Kyung Hee University
Kim Chang-ju Department Of Physiology College Of Medicine Kyung Hee University
Kim Y‐j Chung‐ang Univ. Seoul Kor
Kim Chang-ju Dep. Of Physiology Kyung Hee Univ.

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