A dministration of Folium mori Extract Decreases Nitric Oxide Synthase Expression in the Hypothalamus of Streptozotocin-Induced Diabetic Rats

元データ 2002-10-01 社団法人 日本薬理学会

概要

Folium mori, the leaves of Morus alba L., has traditionally been used for the treatment of diabetic hyperglycemia. It has been shown to induce enhanced NOS expression in the hypothalamus of rats with streptozotocin (STZ)-induced diabetes. In the present study, the effect of Folium mori on the expression of nitric oxide synthase (NOS) in the hypothalamus of STZ-induced diabetic rats was investigated via nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry. Enhanced NAPDH-d expression was detected in the paraventricular nucleus, ventromedial hypothalamic nucleus, and lateral hypothalamic area of the hypothalamus in the STZ-induced diabetes group. Administration of the aqueous extract of Folium mori to rats with STZ-induced diabetes resulted in decreased NADPH-d positivity. These results suggest that Folium mori treatment is effective in curbing the desire for food under diabetic conditions via modulation of NO expression in the hypothalamus.

著者

Kim C‐j Department Of Physiology College Of Medicine Kyung Hee University
Kim C‐j Kyung Hee Univ. Seoul Kor
KIM Eun-Kyung College of Medicine, Kohwang Medical Research Institute, Kyung Hee University
LEE Taeck-Hyun Department of Physiology, College of Medicine, Kyung Hee University
JANG Mi-Hyeon Department of Physiology, College of Medicine, Kyung Hee University
SHIN Min-Chul Department of Physiology, College of Medicine, Kyung Hee University
KIM Hong Department of Physiology, College of Medicine, Kyung Hee University
KIM Chang-Ju Department of Physiology, College of Medicine, Kyung Hee University
KIM Ee-Hwa Department of Acupoint & Meridian, College of Oriental Medicine, Semyung University
LIM Baek-Vin Department of Physiology, College of Medicine, Kyung Hee University
JUNG Sae-Bin Department of Physiology, College of Medicine, Kyung Hee University
Kim Ee-hwa Department Of Physiology College Of Medicine Kyung Hee University
Kim Ee-hwa 韓国
Kim H Department Of Oriental Sports Medicine College Of Health & Therapy Daegu Haany University
Lee T‐h Department Of Physiology College Of Medicine Kyung Hee University
Jang M‐h Department Of Physiology College Of Medicine Kyung Hee University
Shin M‐c Department Of Physiology College Of Medicine Kyung Hee University
Shin Min-chul Department Of Physiology College Of Medicine Kyung Hee University
Lim Baek-vin Department Of Physiology College Of Medicine Kyung Hee University
Jang Mi-hyeon Department Of Physiology College Of Medicine Kyung Hee University
Kim Chang-ju Department Of Physiology College Of Medicine Kyung Hee University
Kim Hong Department Of Oriental Sports Medicine College Of Health & Therapy Daegu Haany University
Lee Taeck-hyun Department Of Physiology College Of Medicine Kyung Hee University
Kim Chang-ju Dep. Of Physiology Kyung Hee Univ.
Kim Hong Department Of Chemistry Advanced Materials Chemistry Research Center Korea University
Kim H Graduate School Of East-west Medical Science Kyung Hee University
Jung Sae-bin Department Of Physiology College Of Medicine Kyung Hee University
Kim Hong Department of Applied Sciences, Korea Maritime University, Busan 606-791, Korea

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