A dministration of Folium mori Extract Decreases Nitric Oxide Synthase Expression in the Hypothalamus of Streptozotocin-Induced Diabetic Rats
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概要
- 論文の詳細を見る
Folium mori, the leaves of Morus alba L., has traditionally been used for the treatment of diabetic hyperglycemia. It has been shown to induce enhanced NOS expression in the hypothalamus of rats with streptozotocin (STZ)-induced diabetes. In the present study, the effect of Folium mori on the expression of nitric oxide synthase (NOS) in the hypothalamus of STZ-induced diabetic rats was investigated via nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry. Enhanced NAPDH-d expression was detected in the paraventricular nucleus, ventromedial hypothalamic nucleus, and lateral hypothalamic area of the hypothalamus in the STZ-induced diabetes group. Administration of the aqueous extract of Folium mori to rats with STZ-induced diabetes resulted in decreased NADPH-d positivity. These results suggest that Folium mori treatment is effective in curbing the desire for food under diabetic conditions via modulation of NO expression in the hypothalamus.
- 社団法人 日本薬理学会の論文
- 2002-10-01
著者
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Kim C‐j
Department Of Physiology College Of Medicine Kyung Hee University
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Kim C‐j
Kyung Hee Univ. Seoul Kor
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KIM Eun-Kyung
College of Medicine, Kohwang Medical Research Institute, Kyung Hee University
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LEE Taeck-Hyun
Department of Physiology, College of Medicine, Kyung Hee University
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JANG Mi-Hyeon
Department of Physiology, College of Medicine, Kyung Hee University
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SHIN Min-Chul
Department of Physiology, College of Medicine, Kyung Hee University
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KIM Hong
Department of Physiology, College of Medicine, Kyung Hee University
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KIM Chang-Ju
Department of Physiology, College of Medicine, Kyung Hee University
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KIM Ee-Hwa
Department of Acupoint & Meridian, College of Oriental Medicine, Semyung University
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LIM Baek-Vin
Department of Physiology, College of Medicine, Kyung Hee University
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JUNG Sae-Bin
Department of Physiology, College of Medicine, Kyung Hee University
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Kim Ee-hwa
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Ee-hwa
韓国
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Kim H
Department Of Oriental Sports Medicine College Of Health & Therapy Daegu Haany University
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Lee T‐h
Department Of Physiology College Of Medicine Kyung Hee University
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Lee Taeck-hyun
韓国
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Jang M‐h
Department Of Physiology College Of Medicine Kyung Hee University
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Shin M‐c
Department Of Physiology College Of Medicine Kyung Hee University
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Shin Min-chul
Department Of Physiology College Of Medicine Kyung Hee University
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Lim Baek-vin
Department Of Physiology College Of Medicine Kyung Hee University
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Jang Mi-hyeon
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Chang-ju
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Hong
Department Of Oriental Sports Medicine College Of Health & Therapy Daegu Haany University
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Lee Taeck-hyun
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Chang-ju
Dep. Of Physiology Kyung Hee Univ.
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Kim Hong
Department Of Chemistry Advanced Materials Chemistry Research Center Korea University
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Kim H
Graduate School Of East-west Medical Science Kyung Hee University
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Jung Sae-bin
Department Of Physiology College Of Medicine Kyung Hee University
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Kim Hong
Department of Applied Sciences, Korea Maritime University, Busan 606-791, Korea
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