Protective Effect of Gabapentin on N-Methyl-D-aspartate-Induced Excitotoxicity in Rat Hippocampal CA1 Neurons

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概要

• 論文の詳細を見る

• Gabapentin was developed as an anticonvulsant, but has also been used to alleviate hyperalgesia in neuropathic pain. In this study, the protective effect of gabapentin against N-methyl-<sc>D</sc>-aspartate (NMDA)-induced excitotoxicity in rat hippocampal CA1 neurons was investigated. Pre-treatment with gabapentin reduced the degree of neuronal damage induced by NMDA exposure in cultured hippocampal slices. Patch-clamp studies revealed that gabapentin significantly inhibited the NMDA receptor–activated ion current in dissociated hippocampal CA1 neurons, resulting in suppression of glutamate-induced neuronal injury. These results show that gabapentin may exert protective effects against glutamate-induced neuronal injury at least in part by inhibiting the NMDA receptor–activated ion current.

• 社団法人 日本薬理学会の論文
• 2009-01-20

著者

• Kim C‐j

  Department Of Physiology College Of Medicine Kyung Hee University

• Kim C‐j

  Kyung Hee Univ. Seoul Kor

• CHANG Hyun-Kyung

  Department of Physiology, College of Medicine, Kyung Hee University

• SHIN Min-Chul

  Department of Physiology, College of Medicine, Kyung Hee University

• KIM Hong

  Department of Physiology, College of Medicine, Kyung Hee University

• KIM Chang-Ju

  Department of Physiology, College of Medicine, Kyung Hee University

• SHIN Mal-Soon

  Department of Physiology, College of Medicine, Kyung Hee University

• Kim Chang-ju

  韓国

• Lee J‐s

  Department Of Physiology College Of Medicine Kyung Hee University

• Kim H

  Department Of Oriental Sports Medicine College Of Health & Therapy Daegu Haany University

• Lee Jong-sung

  Biotoxtech Co. Ltd.

• KIM Sung-Eun

  Department of Biomedical Engineering, College of Medicine, The Catholic University of Korea

• Lee J‐d

  Department Of Microbiology College Of Natural Sciences Pusan National University

• Lee Jun

  Department Of Pharmacy College Of Pharmacy Pusan National University

• Kim Y

  Department Of Physiology College Of Medicine Kyung Hee University

• Sung Yun-hee

  Department Of Physiology College Of Medicine Kyung Hee University

• Kim Y‐s

  Seoul National Univ. Seoul Kor

• Shin M‐c

  Department Of Physiology College Of Medicine Kyung Hee University

• Kim Sangho

  Department Of Physiology College Of Medicine Kyung Hee University

• Chang H‐k

  Department Of Physiology College Of Medicine Kyung Hee University

• Lee Jin-woo

  Department Of Electrical Engineering Korea Advanced Institute Of Science And Technology

• KIM Young-Sick

  Department of Physiology, College of Medicine, Kyung Hee University

• YI Jae-Woo

  Department of Anesthesiology, East-West Neo Medical Center, Kyung Hee University

• PARK Je-Hoon

  Department of Surgery, Ilsan Paik Hospital, Inje University College of Medicine

• Yi Jae-woo

  Department Of Anesthesiology East-west Neo Medical Center Kyung Hee University

• Park Je-hoon

  Department Of Surgery Ilsan Paik Hospital Inje University College Of Medicine

• Kim Chang-ju

  Department Of Physiology College Of Medicine Kyung Hee University

• Lee Jun-sik

  Dep. Of Microbiology And Immunology Pusan National Univ. Coll. Of Medicine

• Kim Hong

  Department Of Oriental Sports Medicine College Of Health & Therapy Daegu Haany University

• Lee Jun-sik

  Department Of Microbiology College Of Natural Sciences Pusan National University

• Lee J

  Kyung Hee Univ. Seoul Kor

• Kim Chang-ju

  Dep. Of Physiology Kyung Hee Univ.

• Kim Hong

  Department Of Chemistry Advanced Materials Chemistry Research Center Korea University

• Sim Young-je

  Department Of Physiology College Of Medicine Kyung Hee University

• Lee Jae-dong

  Department Of Acupuncture & Moxibustion College Of Oriental Medicine Kyunghee University

• Lee Jin-woo

  Department Of Dermatology Kosin University College Of Medicine

• Kim H

  Graduate School Of East-west Medical Science Kyung Hee University

• Kim Sung-eun

  Department Of Biomedical Engineering College Of Medicine The Catholic University Of Korea

• Lee Jin-woo

  Department Of Biomedical Engineering College Of Medicine Kyunghee University

• Kim Young-sick

  Department Of Physiology College Of Medicine Kyung Hee University

• Kim Hong

  Department of Applied Sciences, Korea Maritime University, Busan 606-791, Korea

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