Alleviation of Experimental Septic Shock in Mice by Acidic Polysaccharide Isolated from the Medicinal Mushroom Phellinus linteus(Medicinal Chemistry)

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概要

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• This study reports that acidic polysaccharide (PL) isolated from Phellinus linteus alleviated the septic shock induced by high dose lipopolysaccharide (LPS) injection in mice. To examine the origin of this effect, we investigated cytokine production in serum and the expression of MHC II in B cells and macrophages in areas of inflamation. Pretreatment with PL 24 h before LPS administration resulted in a significant inhibition of up to 68% of circulating tumor necrosis factor (TNF)-α, a moderate reduction of 45% of interleukine (IL)-12 and 23% of IL- 1β, but no significant reduction in IL-6. In addition, the expression of MHC II in B cells and macrophages was examined. Our results show that LPS-stimulated cytokine release and the level of MHC II can be modulated by in vivo administration of soluble PL in mice. The decrease of IL-lβ, IL-12 and TNF-α in sera and the down-modulation of MHC II during septic shock may contribute to the long survival of mice by PL. Administration of PL in vivo decreases IL-2, IFN-γ and TNF-α production in splencotyes and enhances spontaneous cell apoptosis in macrophages and lymphocytes stimulated with LPS in vitro. Thus, part of the anti-inflammatory effects of PL treatment in vivo may result from the enhanced apoptosis of a portion of the activated macrophages and lymphocytes. The ability of PL to significantly reduce the TNF-α production indicates the potential of the polysaccharides in possible therapeutic strategies that are based on down-regulation of TNF-α.

• 社団法人日本薬学会の論文
• 2003-10-01

著者

• Park Yeong-min

  Dep. Of Microbiology And Immunology Pusan National Univ. Coll. Of Medicine

• Park Yeong-min

  Dep. Of Microbiology And Immunology And National Res. Lab. Of Dendritic Cell Differentiation & R

• Ahn Soon-cheol

  韓国

• Ahn Soon-cheol

  Department Of Microbiology & Immunology And National Research Laboratory Of Dendritic Cell Diffe

• LEE Jae-Dong

  Department of Microbiology, College of Natural Sciences, Pusan National University

• PARK Yeong-Min

  Department of Microbiology & Immunology, and National Research Laboratory of Dendritic Cell Differen

• KIM Gi-Young

  Department of Microbiology, College of Natural Sciences, Pusan National University

• ROH Su-In

  Department of Microbiology, Pusan National University College of Medicine

• PARK Soon-Kew

  Department of Internal Medicine, Pusan National University College of Medicine

• OH Yang-Hyo

  Department of Microbiology, Pusan National University College of Medicine

• Roh Su-in

  Department Of Microbiology Pusan National University College Of Medicine

• Roh Su-in

  韓国

• Lee J‐d

  Department Of Microbiology College Of Natural Sciences Pusan National University

• Kim Gi-young

  韓国

• Kim Gi-young

  Faculty Of Applied Marine Science Cheju National University

• Lee Jun

  Department Of Pharmacy College Of Pharmacy Pusan National University

• Oh Yang-hyo

  Department Of Microbiology Pusan National University College Of Medicine

• Park S‐k

  Department Of Internal Medicine Pusan National University College Of Medicine

• Lee Jun-sik

  Dep. Of Microbiology And Immunology Pusan National Univ. Coll. Of Medicine

• Park Yeong-min

  Department Of Microbiology & Immunology And National Research Laboratory Of Dendritic Cell Diffe

• Lee Jun-sik

  Department Of Microbiology College Of Natural Sciences Pusan National University

• Park Soon-kew

  Department Of Internal Medicine Pusan National University College Of Medicine

• Lee Jae-dong

  Department Of Acupuncture & Moxibustion College Of Oriental Medicine Kyunghee University

• Park Young-mi

  Department Of Microbiology And Immunology And National Research Laboratory Of Dendritic Cell Differe

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