Partial Characterization and Immunostimulatory Effect of a Novel Polysaccharide-Protein Complex Extracted from Phellinus linteus

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概要

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• Many polysaccharides isolated from mushroom are considered to be biological response modifiers and have been shown to enhance various immune responses in vivo and in vitro. We demonstrate that a novel polysaccharide–protein complex (PPC) extracted from Phellinus linteus was a potent immunomodulator. PPC had a molecular weight of approximately 73 kDa. It was composed of five different monosaccharides, predominantly D-glucose and D-mannose, in the molar ratio of 3:2, the main amino acid being aspartic acid. PPC had a unique mode of immunostimulation with regard to its cell-type specificity. PPC was found to markedly increase the proliferation of B cells, but not T cells. Although PPC and lipopolysaccharide (LPS) had a similar mode of action in B cells, they were differentiated by the fact that PPC-induced cellular activation was not inhibited by polymyxin B (PB), a specific inhibitor of LPS. PPC increased the cytokine production and nitric oxide (NO) from macrophages. PPC also enhanced the lytic death of NO-sensitive tumor cells, B16 melanoma, through the production of NO. In addition, PPC up-regulated the natural killer (NK) cell-mediated killing of tumor cells, YAC-1 lymphoma in vitro. These results suggest that PPC stimulated the tumoricidal activities of macrophages and NK cells, and induced the proliferation of B cells in vitro. This process may be the mechanism by which PPC produced its therapeutic effects.

• 社団法人 日本農芸化学会の論文
• 2006-05-23

著者

• Choi Byung

  韓国

• CHOI Yung

  Department of Oriental Medicine, Dongeui University College of Oriental Medicine

• KIM Gi-Young

  Faculty of Applied Marine Science, Cheju National University

• Choi Yung

  韓国

• Lee J‐d

  Department Of Microbiology College Of Natural Sciences Pusan National University

• Jeong Young-il

  Department Of Microbiology And Immunology National Research Laboratory Of Dendritic Cell Differentia

• Kim Gi-young

  韓国

• Kim Gi-young

  Faculty Of Applied Marine Science Cheju National University

• Lee Jun

  Department Of Pharmacy College Of Pharmacy Pusan National University

• Choi Yung

  Department Of Oriental Medicine Dongeui University College Of Oriental Medicine

• Jeong Sang-chul

  Faculty Of Applied Marine Science Cheju National University

• Lee Ki-wan

  Faculty Of Applied Marine Science Cheju National University

• LEE Jae-Yoon

  Department of Oriental Medicine, Dongeui University College of Oriental Medicine

• RYU Chung-Ho

  Department of Microbiology, College of Natural Sciences, Pusan National University

• Choi Byung

  Department Of Pediatrics St Mary's Hospital The Catholic University Of Korea

• Lee Jun-sik

  Dep. Of Microbiology And Immunology Pusan National Univ. Coll. Of Medicine

• LEE Jeong-Ok

  Division of Applied Life Science, Gyeongsang National University

• RYU Chung-Ho

  Division of Applied Life Science, Gyeongsang National University

• JEONG Yong-Ki

  Department of Microbiology, Dongeui University

• Kim Yong

  Department Of Microbiology And Immunology National Research Laboratory Of Dendritic Cell Differentia

• Lee Jun-sik

  Department Of Microbiology College Of Natural Sciences Pusan National University

• Choi Byung

  Department Of Civil Engineering Sungkyunkwan University

• Choi Yung

  Department Of Biochemistry Dongeui University College Of Oriental Medicine

• Ryu Chung-ho

  Department Of Microbiology College Of Natural Sciences Pusan National University

• Lee Jae-yoon

  Department Of Microbiology College Of Natural Sciences Pusan National University

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