Dendritic Cell-Tumor Fusion Vaccine Prevents Tumor Growth in Vivo
スポンサーリンク
概要
- 論文の詳細を見る
Dendritic cells (DCs) are potent antigen presenting cells that are uniquely effective in generating primary immune responses. DCs that are manipulated to present tumor antigens induce antitumor immunity in animal models and preclinical human studies. A myriad of strategies have been developed to load tumor antigen effectively onto DCs. DC-tumor fusion presents a spectrum of tumor-associated antigens to helper T- and cytotoxic T-cell populations in the context of DC-mediated costimulatory signals. In this study, fusion cells (FCs) were generated with MCA-102 fibrosarcoma cells and murine bone marrow-derived myeloid DCs. The FCs coexpressed the DC-derived MHC class II and costimulatory molecules. The FCs also retained the functional properties of DCs and stimulated syngeneic T cell proliferation and interferon-γ (IFN-γ) production. Significantly, the results show that syngeneic T cells are primed by FCs to induce MHC class I-dependent lysis of MCA-102 fibrosarcoma. These findings indicate that fusions of tumor cells and DCs activate T-cell responses against syngeneic tumors.
- 社団法人 日本農芸化学会の論文
- 2007-01-23
著者
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Park Yeong-min
Dep. Of Microbiology And Immunology Pusan National Univ. Coll. Of Medicine
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Park Yeong-min
Dep. Of Microbiology And Immunology And National Res. Lab. Of Dendritic Cell Differentiation & R
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MOON Dong-Oh
Faculty of Applied Marine Science, Cheju National University
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CHOI Yung
Department of Oriental Medicine, Dongeui University College of Oriental Medicine
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LEE Chang-Min
Department of Microbiology & Immunology, and National Research Laboratory of Dendritic Cell Differen
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PARK Yeong-Min
Department of Microbiology & Immunology, and National Research Laboratory of Dendritic Cell Differen
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KIM Gi-Young
Faculty of Applied Marine Science, Cheju National University
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Lee Kyu-sub
Dep. Of Obstetrics And Gynecology Pusan National Univ. Coll. Of Medicine
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Choi Yung
韓国
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Moon Dong-oh
韓国
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Lee J‐d
Department Of Microbiology College Of Natural Sciences Pusan National University
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Jeong Young-il
Department Of Microbiology And Immunology National Research Laboratory Of Dendritic Cell Differentia
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Jeong Young-il
Department Of Dermatology Asan Medical Center College Of Medicine University Of Ulsan
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Moon Dong-oh
Faculty Of Applied Marine Science Cheju National University
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Kim Gi-young
韓国
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Kim Gi-young
Faculty Of Applied Marine Science Cheju National University
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Lee Jun
Department Of Pharmacy College Of Pharmacy Pusan National University
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Lee Chang-min
韓国
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Chae Ho-Jin
Department of Obstetrics and Gynecology, Pusan National University College of Medicine
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Kim Ki-Hyung
Department of Obstetrics and Gynecology, Pusan National University College of Medicine
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YOON Man-Soo
Department of Obstetrics and Gynecology, Pusan National University College of Medicine
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LEE Kyu-Sub
Department of Obstetrics and Gynecology, Pusan National University College of Medicine
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LEE Jun-Sik
Department of Microbiology and Immunology, Pusan National University College of Medicine
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Lee Jun-sik
Dep. Of Microbiology And Immunology Pusan National Univ. Coll. Of Medicine
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Park Yeong-min
Department Of Microbiology & Immunology And National Research Laboratory Of Dendritic Cell Diffe
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Kim Yong
Department Of Microbiology And Immunology National Research Laboratory Of Dendritic Cell Differentia
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Lee Jun-sik
Department Of Microbiology College Of Natural Sciences Pusan National University
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Lee Chang-min
Department Of Microbiology And Immunology National Research Laboratory Of Dendritic Cell Differentia
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Choi Yung
Department Of Biochemistry Dongeui University College Of Oriental Medicine
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Kim Ki-hyung
Department Of Computer Engineering Yeungnam University
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Yoon Man-soo
Department Of Obstetrics And Gynecology College Of Medicine Pusan National University
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Lee Jae-dong
Department Of Acupuncture & Moxibustion College Of Oriental Medicine Kyunghee University
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Chae Ho-jin
Department Of Obstetrics And Gynecology Pusan National University College Of Medicine
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Yoon Man-soo
Department Of Obstetrics And Gynecology Pusan National University College Of Medicine
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Kim Ki-hyung
Department Of Obstetrics And Gynecology Pusan National University College Of Medicine
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Park Young-mi
Department Of Microbiology And Immunology And National Research Laboratory Of Dendritic Cell Differe
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