Uncaria rhynchophylla Induces Angiogenesis in Vitro and in Vivo(Pharmacognosy)
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概要
- 論文の詳細を見る
Angiogenesis consists of the proliferation, migration, and differentiation of endothelial cells, and angiogenic factors and matrix protein interactions modulate this process. The aim of this study was to determine the angiogenic properties of Uncaria rhynchophylla. Uncaria rhynchophylla significantly enhanced human umbilical vein endothelial cells (HUVECs) proliferation in a dose-dependent manner. Neutralization of vascular endothelial growth factor (VEGF) or basic fibroblast growth factor (bFGF) by monoclonal antibody suppressed the Uncaria rhynchophylla stimulatory effect on proliferation. In addition, Uncaria rhynchophylla significantly increased chemotactic-migration on gelatin and tubular structures on Matrigel of HUVECs in a dose-dependent manner. Interestingly, Uncaria rhynchophylla dose-dependently increased VEGF, and bFGF gene expression and protein secretion of HUVEC. The angiogenic activity of Uncaria rhynchophylla was confirmed using an in vivo Matrigel angiogenesis model, showing promotion of blood vessel formation. These results suggest that Uncaria rhynchophylla could potentially used to accelerate vascular wound healing or to promote the growth of collateral blood vessel in ischemic tissues.
- 公益社団法人日本薬学会の論文
- 2005-12-01
著者
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Kim Kang
Department Of Theoretical And Computational Molecular Science Institute For Molecular Science
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LEE Jae
Department of Metallurgy, The University of Tokyo
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Park Dong
Department Of Radio Science And Engineering Chungnam National University
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Choi Do-young
Department Of Acupuncture & Moxibustion College Of Oriental Medicine Kyunghee University
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Cho Yoon
Department Of Pharmacy Seoul National University Hospital
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Kim Kang
Department Of Orthopedic Surgery College Of Medicine
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Cho Eun
Oriental Medicine Research Center For Bone & Joint Disease
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Park Dong
Department Of Acupuncture & Moxibustion College Of Oriental Medicine
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Cho Yoon
Department Of Orthopedic Surgery College Of Medicine
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Baek Yong
Department Of Acupuncture & Moxibustion College Of Oriental Medicine
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Yang Ha
Oriental Medicine Research Center For Bone & Joint Disease
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Lee Jae-dong
Department Of Acupuncture & Moxibustion College Of Oriental Medicine Kyunghee University
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Lee Jae
Department Of Acupuncture & Moxibustion College Of Oriental Medicine
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Kim Deog
Department Of Nuclear Medicine College Of Medicine Kyung Hee University
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CHOI Do
Department of Acupuncture & Moxibustion, College of Oriental Medicine
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HUH Jeong
Oriental Medicine Research Center for Bone & Joint Disease
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Choi Do
Department Of Acupuncture & Moxibustion College Of Oriental Medicine
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Huh Jeong
Oriental Medicine Research Center For Bone & Joint Disease
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Kim Kang
Department Of Computational Molecular Science Institute For Molecular Science
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Cho Yoon
Department Of Chemistry And Chemistry Institute For Functional Materials Pusan National University
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Huh Jeong-eun
Oriental Medicine Res. Center For Bone & Joint Disease Kyung Hee Univ.
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Kim Kang
Department of Applied Physics, Hanyang University, Sa-1 Dong, Ansan 426-791, Korea
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