Effect of Betula platyphylla var. japonica on Proteoglycan Release, Type II Collagen Degradation, and Matrix Metalloproteinase Expression in Rabbit Articular Cartilage Explants(Pharmacognosy)
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概要
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Articular cartilage is a potential target for drugs designed to inhibit the activity of matrix metalloproteinases (MMPs) to stop or slow the destruction of proteoglycan and collagen in the cartilage extracellular matrix. The purpose of this study was to investigate the effects of Betula platyphylla var. japonica on inhibiting the release of glycosaminoglycan (GAG), the degradation of collagen, and MMP expression and activity in rabbit articular cartilage explants. Interleukin-1α (IL-1α) rapidly induced GAG, but collagen was much less readily released from cartilage explants. Betula platyphylla var. japonica significantly inhibited GAG and collagen release in a concentration-dependent manner. Betula platyphylla var. japonica dose-dependently inhibited MMP-3 and MMP-13 expression and activities from IL-1α-treated cartilage explant culture when tested at concentrations ranging from 0.02 to 0.2mg/ml. Betula platyphylla var. japonica had no harmful effect on chondrocyte viability or cartilage morphology in cartilage explants. Histological analysis indicated that Betula platyphylla var. japonica reduced the degradation of the cartilage matrix compared with that of IL-1α-treated cartilage explants. These results indicate that Betula platyphylla var. japonica inhibits the degradation of proteoglycan and collagen through the down regulation of MMP-3 and MMP-13 expression and activities without affecting the viability or morphology of IL-1α-stimulated rabbit articular cartilage explants.
- 社団法人日本薬学会の論文
- 2006-07-01
著者
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KIM Nam-Jae
East-West Medical Research Institute, College of Pharmacy
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Kim Nam-jae
East-west Medical Research Institute
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Kim Nam-jae
East-west Medical Institute Kyung Hee University
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Park Dong-suk
Department Of Acupuncture & Moxibustion East-west Neo Medical Center Kyunghee University
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LEE Jae-Dong
Department of Microbiology, College of Natural Sciences, Pusan National University
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Choi Do-young
Department Of Acupuncture & Moxibustion College Of Oriental Medicine Kyunghee University
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Huh Jeong-eun
Oriental Medicine Research Center For Bone And Joint Disease Kyunghee University
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BAEK Yong-Hyeon
Department of Acupuncture & Moxibustion, East-West Neo Medical Center, KyungHee University
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CHO Yoon-Je
Department of Orthopedic Surgery, College of Medicine
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KIM Deog-Yoon
Department of Nuclear Medicine College of Medicine
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CHO Eun-Mi
Oriental Medicine Research Center for Bone & Joint Disease
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YANG Ha-Ru
Oriental Medicine Research Center for Bone & Joint Disease
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Cho Eun-mi
Oriental Medicine Research Center For Bone & Joint Disease
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Cho Yoon-je
Department Of Orthopedic Surgery College Of Medicine
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Cho Yoon-je
Department Of Orthopaedic Surgery School Of Medicine Kyung-hee University
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Baek Yong-hyeon
Department Of Acupuncture & Moxibustion East-west Neo Medical Center Kyunghee University
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Yang Ha-ru
Oriental Medicine Research Center For Bone & Joint Disease
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Lee Jae-dong
Department Of Acupuncture & Moxibustion College Of Oriental Medicine Kyunghee University
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Huh Jeong-eun
Oriental Medicine Res. Center For Bone & Joint Disease Kyung Hee Univ.
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