β-Glucuronidase-Inhibitory Activity and Hepatoprotective Effect of Ganoderma lucidum
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概要
- 論文の詳細を見る
To prove the relationship between the fluctuation in serum β-glucuronidase level and hepatotoxicity, an inhibitor of β-glucuronidase from G. lucidum was isolated and its hepatoprotective activity was investigated. The ether fraction of G. lucidum, which had potent β-glucuronidase-inhibitory activity, protected against CCl_4-induced liver injury. From this ether fraction, ganoderenic acid A, was isolated as the potent inhibitor of β-glucuronidase. It had a potent hepatoprotective effect against CCl_4-induced liver injury. These results suggest that the β-glucuronidase seems to be closely related to liver injury, which could be prevented by β-glucuronidase inhibitors.
- 社団法人日本薬学会の論文
- 1999-02-15
著者
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Kim Dong-hyun
College Of Pharmacy Kyung Hee University
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KIM Nam-Jae
East-West Medical Research Institute, College of Pharmacy
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Kim Nam-jae
East-west Medical Institute Kyung Hee University
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SHIM Sang-Bum
College of Pharmacy Kyung Hee University
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JANG Il-Sung
College of Pharmacy Kyung Hee University
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Kim Do-hoon
Department Of Psychiatry College Of Medicine Institute Of Natural Medicine Hallym University
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Kim D‐h
Department Of Psychiatry College Of Medicine Institute Of Natural Medicine Hallym University
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Kim Dong-hyun
College Of Pharmacy
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