Metabolism of Quercitrin by Human Intestinal Bacteria and Its Relation to Some Biological Activities
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概要
- 論文の詳細を見る
When quercitrin was anaerobically incubated with human intestinal becteria, quercetin, 3,4-dihydroxyphenylacetic acid and 4-hydroxybenzoic acid were found as metabolites. The main metabolite was quercetin. The bacterium transforming quercitrin to quercetin was Fusobacterium K-60. However, Bacteroides, JY-6,which produced α-L-rhamnosidase, did not transform quercitrin to quercetin. Among quercitrin and its metabolites, 3,4-dihydroxyphenylacetic acid and 4-hydroxylphenylacetic acid had more potent activity than quercitrin on in vitro anti-platelet aggregation activity, and quercetin and 3,4-dihydroxyphenylacetic acid showed more potent cytotoxicity against tumor cell lines than quercitrin and 4-hydroxylphenylacetic acid.
- 社団法人日本薬学会の論文
- 1999-07-15
著者
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Shin Yong
College Of Pharmacy Kyung Hee University
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Kim Dong-hyun
College Of Pharmacy Kyung Hee University
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HAN Myung
Department of Food and Nutrition, Kyung Hee University
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CHOO Min-Kyung
College of Pharmacy, Kyung Hee University
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PARK Sun-Young
College of Pharmacy, Kyung Hee University
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KIM Suk-Young
College of Pharmacy, Kyung-Hee University
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Han Myung
Department Of Food And Nutrition Kyung Hee University
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Park Sun-young
College Of Pharmacy Kyung Hee University
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Park Sun-young
韓国
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Kim Suk-young
韓国
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Kim Suk-young
College Of Pharmacy Kyung-hee University
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Kim Deog
College Of Pharmacy Kyung Hee University
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Choo Min-kyung
College Of Pharmacy Kyung Hee University
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Choo Min-kyung
韓国
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Kim D‐h
College Of Pharmacy Kyung Hee University
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Park S‐y
College Of Pharmacy Kyung Hee University
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Park S‐y
Korea Res. Inst. Biosci. And Biotechnol. Taejon Kor
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Han Myung
Dep. Of Food And Nutrition Kyung Hee Univ.
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Kim Dong-hyun
Department Of Life And Nanopharmaceutical Sciences And Department Of Pharmaceutical Science Kyung He
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Park Sun-young
College Of Pharmacy Kyung-hee University
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Kim D‐h
Taegu Univ. Kyungbuk Kor
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Kim Dong-hyun
College Of Pharmacy
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