Stereospecific Effects of Ginsenoside Rg_3 Epimers on Swine Coronary Artery Contractions(Pharmacology)
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概要
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Previous reports have shown that ginseng saponins, the active ingredients of Panax ginseng, induce relaxation of hormone- or high K^+-induced blood vessel contraction. We recently demonstrated that 20(R)- and 20(S)-ginsenoside Rg_3 epimers regulate ion channel activities in a stereospecific manner. Here, we examined whether ginsenoside Rg_3 epimers also exhibit differential effects on swine coronary artery contractions induced by high K^+ or 5-HT. We found that treatment with 20(S)- but not 20(R)-ginsenoside Rg_3 caused a potent concentration-dependent, endothelium-independent relaxation of coronary artery contraction induced by 25 mM KCl. However, treatment with both 20(S)- and 20(R)-ginsenoside Rg_3 induced a significant, concentration-dependent relaxation of 3μM 5-HT-induced coronary artery contractions in intact samples, while only 20(S)-ginsenoside Rg_3 inhibited coronary artery contraction in endothelium-denuded arteries. 20(S)- but not 20(R)-ginsenoside Rg_3 inhibited L-type Ca^<2+> channel currents in a dose- and voltage-dependent manner. These results indicate that 20(S)- and 20(R)-ginsenoside Rg_3 epimers might exhibit stereospecific relaxation effects on swine coronary artery contractions caused by high K^+ and 5-HT receptor activation.
- 社団法人日本薬学会の論文
- 2006-02-01
著者
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Kim Dong-hyun
College Of Pharmacy Kyung Hee University
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Kim Bo-ra
Ginsentology Research Laboratory And Department Of Physiology College Of Veterinary Medicine Konkuk
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Lee Jun-ho
Department Of Physiology College Of Oriental Medicine Kyung-hee University
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CHOI Sun-Hye
Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konku
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LEE Byung-Hwan
Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konku
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NAH Seung-Yeol
Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konku
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LEE Jun-Ho
Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konku
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YOON In-Soo
Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konku
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LEE Joon-Hee
Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konku
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JEONG Sang
Ginsentology Research Laboratory, Department of Physiology, College of Veterinary Medicine
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KIM Jong-Hoon
Ginsentology Research Laboratory, Department of Physiology, College of Veterinary Medicine, and Bio
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PARK Tae-Kyu
Department of Biotechnology, College of Natural Science, Konkuk University
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KIM Bo-Kyung
College of Medicine, Konkuk University
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Choi Sun
Ginsentology Research Laboratory And Department Of Physiology College Of Veterinary Medicine Konkuk
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Yoon In
Ginsentology Research Laboratory And Department Of Physiology College Of Veterinary Medicine Konkuk
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Nah Seung-yeol
Ginsentology Research Laboratory And Department Of Physiology College Of Veterinary Medicine Konkuk
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Nah Seung-yeol
Department Of Physiology College Of Veterinary Medicine Chonnam National University
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Nah Seung-yeol
Bio Molecular Informatics Center Konkuk University
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Lee Byung-hwan
Ginsentology Research Laboratory And Department Of Physiology College Of Veterinary Medicine Konkuk
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Jeong Sang
Department Of Physiology College Of Veterinary Medicine Konkuk University:department Of Physiology A
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Park Tae-kyu
Ambo Institute
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Park Tae-kyu
Department Of Biotechnology College Of Biomedical And Health Science Konkuk University
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Kim Jong-hoon
Department Of Physiology College Of Veterinary Medicine Konkuk University
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Cho Ssang-goo
Bio Molecular Informatics Center Konkuk University
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Kim Dong-hyun
College Of Pharmacy
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