Ginseng Saponins Diminish Adverse Vascular Effects Associated with Chronic Methionine-Induced Hyperhomocysteinemia(Pharmacognosy)

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Recent studies have shown that Panax ginseng has a variety of beneficial effects on the cardiovascular systems. Homocysteine (Hcy), which is derived from L-methionine (Met), has been closely associated with the increased risk of cardiovascular diseases. In the present study, we examined whether in vivo long-term administration of ginseng saponins (GS), active ingredients of Panax ginseng, attenuate adverse vascular effects associated with chronic Met-induced hyperhomocysteinemia (H-Hcy). We found that plasma Hcy level, which was measured after 30 and 60 d, in GS (100mg/kg)+Met co-administration group was significantly reduced when it was compared with Met alone treatment group. We could also observe the alleviation of endothelial damages of aortic artery vessels in GS (100mg/kg)+Met co-administration group compared with Met alone treatment group. We compared aortic vasocontractile and vasodilatory responses between Met alone and GS (100mg/kg) +Met co-treatment groups. We found that norepinephrine-induced vasocontractile responses were greatly decreased in GS (100mg/kg)+Met co-treatment group and that carbachol-induced dilatory responses were greatly enhanced in GS (100mg/kg)+Met co-administration groups as compared with Met alone treatment group. The present results indicate that in vivo long-term administration of GS attenuates adverse vascular effects associated with chronic Met-induced H-Hcy in rats.
社団法人日本薬学会の論文
2006-12-01