Induction of Apoptotic Cell Death by Synthetic Naringenin Derivatives in Human Lung Epithelial Carcinoma A549 Cells(Molecular and Cell Biology)
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概要
- 論文の詳細を見る
Although flavonoids, which are both qualitatively and quantitatively one of the largest groups of natural products, exhibit a variety of beneficial health effects, the exact molecular mechanism of the cellular activities is still not fully explained and there currently exists a lack of evidence for any relationship between the structure-activity relationship and apoptosis-inducing activity. In order to determine the importance of the OH group or substitution of the 5 or carbon-7 in the diphenylpropane skeleton of flavonoids, we originally synthesized several modified naringenin derivatives, including 7-O-benzyl naringenin (KUF-1) and 7-O-(MeO-L-Leu-D-Pro-carbonylmethyl) naringenin (KUF-7). Treatment with KUF-1 or KUF-7 resulted in significant apoptosis-inducing effects concomitant with chromatin condensation, caspase activation, and intracellular ROS production. Our data indicate that originally synthesized naringenin derivatives, KUF-1 and KUF-7 differentially regulate the apoptosis of A549 cells via intracellular ROS production coupled with the concomitant activation of the caspase cascade signaling pathway, thereby implying that hydroxylation or substitution at Carbon-7 is critical for the apoptosis-inducing activity of flavonoids.
- 公益社団法人日本薬学会の論文
- 2007-12-01
著者
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KIM Jung-Hyun
Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University
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HAN Ye
Bio Molecular Informatics Center, Konkuk University
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PAIK Hyun-Dong
Bio Molecular Informatics Center, Konkuk University
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Kim Jung-hyun
韓国
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Kim Jung-hyun
Department Of Animal Biotechnology Konkuk University
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Choi Sun
Ginsentology Research Laboratory And Department Of Physiology College Of Veterinary Medicine Konkuk
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Han Ye
Bio Molecular Informatics Center Konkuk University
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Choi Hye-yeon
Department Of Animal Biotechnology Konkuk University
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Kang Yong-jin
Department Of Animal Biotechnology And Bio Molecular Informatics Center Konkuk University
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Kim Bong-woo
Department Of Animal Biotechnology Konkuk University
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Nah Seung-yeol
Ginsentology Research Laboratory And Department Of Physiology College Of Veterinary Medicine Konkuk
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Nah Seung-yeol
Department Of Physiology College Of Veterinary Medicine Chonnam National University
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Nah Seung-yeol
Bio Molecular Informatics Center Konkuk University
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Cho Ssang-goo
Bio Molecular Informatics Center Konkuk University
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Paik Hyun-dong
韓国
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Park Yong-sun
Bio Molecular Informatics Center Konkuk University
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LEE Eung-Ryoung
Department of Animal Biotechnology, Konkuk University
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CHO Ssang-Goo
Department of Animal Biotechnology, Konkuk University
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KANG Geun-Ho
Department of Animal Biotechnology, RCTCP
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Kang Geun-ho
Department Of Animal Biotechnology Rctcp:bio Molecular Informatics Center Konkuk University
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Lee Eung-ryoung
Department Of Animal Biotechnology Konkuk University
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Paik Hyun-dong
Bio Molecular Informatics Center Konkuk University
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Cho Ssang-goo
Department Of Animal Biotechnology Konkuk University
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Cho Ssang-goo
Department Of Animal Biotechnology College Of Animal Bioscience And Technology Konkuk University
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