Effect of Ginseng Saponins on a Rat Visceral Hypersensitivity Model(Biopharmacy)
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概要
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The 5-hydroxytryptamine_<3A> (5-HT_3) receptor is closely related with irritable bowel syndrome (IBS) in enteric nervous systems. We previously demonstrated that ginseng total saponins (GTS, also called ginsenosides), the active ingredients of Panax ginseng, inhibit the activity of 5-HT_<3A> receptor channels expressed in Xenopus laevis oocytes. Here, we further investigated whether the in vitro inhibitory effect of ginsenosides on 5-HT_<3A> receptor channel activity is coupled to in vivo attenuation of IBS. A rat model of IBS was induced by colorectal distention (CRD) and intracolonic infusion of 0.6% acetic acid (CRD-acetic acid), and visceral hypersensitivity was assessed by counting the contractions in the external oblique muscles of conscious rats during the 10min distention period. We found that oral administration of GTS significantly and dose-dependently inhibited CRD-acetic acid-induced visceral hypersensitivity. The EC_<50> was 5.5±4.7mg/kg (95% confidence intervals : 1.2-15.7) and the inhibitory effect of GTS against visceral hypersensitivity persisted for 4h. When we compared the effects of protopanaxadiol (PD) ginsenosides and protopanaxatriol (PT) ginsenosides against CRD-acetic acid-induced visceral hypersensitivity, we found that PT but not PD ginsenosides significantly attenuated the CRD-acetic acid-in-duced visceral hypersensitivity. These results indicate that PT ginsenosides of Panax ginseng might be the main active components for the attenuation of experimentally CRD-acetic acid-induced visceral hypersensitivity, and may be clinically relevant for the future treatment of IBS.
- 社団法人日本薬学会の論文
- 2005-11-01
著者
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Lee Jun-ho
Department Of Physiology College Of Oriental Medicine Kyung-hee University
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JEONG Sang
Ginsentology Research Laboratory, Department of Physiology, College of Veterinary Medicine
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KIM Jong-Hoon
Ginsentology Research Laboratory, Department of Physiology, College of Veterinary Medicine, and Bio
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KIM Jong
Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konku
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LEE Jun
Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konku
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LEE Byung
Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konku
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YOON In
Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konku
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LEE Joon
Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konku
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CHOI Sun
Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konku
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NAH Seung
Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konku
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Choi Sun
Ginsentology Research Laboratory And Department Of Physiology College Of Veterinary Medicine Konkuk
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Yoon In
Ginsentology Research Laboratory And Department Of Physiology College Of Veterinary Medicine Konkuk
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Nah Seung-yeol
Ginsentology Research Laboratory And Department Of Physiology College Of Veterinary Medicine Konkuk
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Nah Seung-yeol
Department Of Physiology College Of Veterinary Medicine Chonnam National University
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Nah Seung-yeol
Bio Molecular Informatics Center Konkuk University
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Lee Byung-hwan
Ginsentology Research Laboratory And Department Of Physiology College Of Veterinary Medicine Konkuk
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Jeong Sang
Department Of Physiology College Of Veterinary Medicine Konkuk University:department Of Physiology A
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Kim Jong-hoon
Department Of Physiology College Of Veterinary Medicine Konkuk University
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Cho Ssang-goo
Bio Molecular Informatics Center Konkuk University
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Lee Ju-Ho
Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konkuk University
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