The Anti-apoptotic and Anti-oxidant Effect of Eriodictyol on UV-Induced Apoptosis in Keratinocytes(Molecular and Cell Biology)
スポンサーリンク
概要
- 論文の詳細を見る
Recently, considerable scientific and therapeutic interest has focused on the structure and functions of the flavonoids. In a previous study, we suggested that hydroxyl (OH) substitutions on specific carbons in the skeleton of the flavonoids might significantly affect their apoptosis-modulating properties. Here, to investigate the effect of various OH substitutions on their diphenylpropane (C6C3C6) skeleton carbons, we selected 10 different flavonoids and assessed their role on UV-induced apoptosis of human keratinocytes, the principal cell type of epidermis. The results showed that 5,7,3',4'-tetrahydroxylflavanone (eriodictyol) and 3,4'-dihydroxy flavone (3,4'-DHF) had a positive effect on cell proliferation of human HaCaT keratinocytes. Treatment with eriodictyol in particular resulted in significant suppression of cell death induced by ultraviolet (UV) light, a major skin-damaging agent. We found that eriodictyol treatment apparently reduced the percentage of apoptotic cells and the cleavage of poly(ADP-ribose) polymerase, concomitant with the repression of caspase-3 activation and reactive oxygen species (ROS) generation. The anti-apoptotic and anti-oxidant effects of eriodictyol were also confirmed in UV-induced cell death of normal human epidermal keratinocyte (NHEK) cells. Taken together, these findings suggest that eriodictyol can be used to protect keratinocytes from UV-induced damage, implying the presence of a complex structure-activity relationship (SAR) in the differential apoptosis-modulating activities of various flavonoids.
- 公益社団法人日本薬学会の論文
- 2007-01-01
著者
-
KIM Jung-Hyun
Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University
-
Kim Jung-hyun
韓国
-
Kim Jung-hyun
Department Of Animal Biotechnology Konkuk University
-
Choi Sun
Ginsentology Research Laboratory And Department Of Physiology College Of Veterinary Medicine Konkuk
-
Kang Yong-jin
Department Of Animal Biotechnology And Bio Molecular Informatics Center Konkuk University
-
Cho Ssang-goo
Bio Molecular Informatics Center Konkuk University
-
LEE Eung-Ryoung
Department of Animal Biotechnology, Konkuk University
-
CHO Ssang-Goo
Department of Animal Biotechnology, Konkuk University
-
Lee Eung-ryoung
Department Of Animal Biotechnology Konkuk University
-
Cho Ssang-goo
Department Of Animal Biotechnology Konkuk University
-
Cho Ssang-goo
Department Of Animal Biotechnology College Of Animal Bioscience And Technology Konkuk University
関連論文
- 顆粒球コロニー刺激因子による犬拡張型心筋症3例の治療試験(短報)(内科学)
- The Effects of Ginsenoside Rg_3 on Human Kv1.4 Channel Currents without the N-Terminal Rapid Inactivation Domain(Pharmacology)
- Mutations Leu427, Asn428, and Leu431 Residues within Transmembrane Domain-I-Segment 6 Attenuate Ginsenoside-Mediated L-Type Ca2+ Channel Current Inhibitions
- Differential Regulations of Quercetin and Its Glycosides on Ligand-Gated Ion Channels(Pharmacology)
- Modifications of Aliphatic Side Chain of 20(S)-Ginsenoside Rg_3 Cause an Enhancement or Loss of Brain Na^+ Channel Current Inhibitions(Highlighted paper selected by Editor-in-chief,Pharmacology)
- Effects of Ginsenosides, Active Ingredients of Panax ginseng, on Development, Growth, and Life Span of Caenorhabditis elegans(Highlighted paper selected by Editor-in-chief,Pharmacognosy)
- Mutations of Arginine 222 in Pre-transmembrane Domain I of Mouse 5-HT_ Receptor Abolish 20(R)- But Not 20(S)-Ginsenoside Rg_3 Inhibition of 5-HT-Mediated Ion Currents(Pharmacology)
- Ginseng Saponins Diminish Adverse Vascular Effects Associated with Chronic Methionine-Induced Hyperhomocysteinemia(Pharmacognosy)
- Cloning and Heterologous Expression of a Ca^-Activated Chloride Channel Isoform from Rat Brain(Molecular and Cell Biology)
- Stereospecific Effects of Ginsenoside Rg_3 Epimers on Swine Coronary Artery Contractions(Pharmacology)
- Effect of Ginseng Saponins on a Rat Visceral Hypersensitivity Model(Biopharmacy)
- Extracts from Schizandra chinensis Fruit Activate Estrogen Receptors : A Possible Clue to Its Effects on Nitric Oxide-Mediated Vasorelaxation(Pharmacology)
- A Role for the Val291 Residue within the Transmembrane Domain 2 in Diltiazem- and TMB-8 [3,4,5-Trimethoxybenzoic Acid 8-(Diethylamino)octyl Ester]-Mediated 5-Hydroxytryptamine Type 3A Receptor Regulations
- Comparison of Mercury Removal Efficiency from a Simulated Exhaust Gas by Several Types of TiO_2 under Various Light Sources
- Differential Regulation of the Antiapoptotic Action of B-Cell Lymphoma 2 (Bcl-2) and B-Cell Lymphoma Extra Long (Bcl-xL) by c-Jun N-Terminal Protein Kinase (JNK) 1-Involved Pathway in Neuroglioma Cells(Molecular and Cell Biology)
- Induction of Apoptotic Cell Death by Synthetic Naringenin Derivatives in Human Lung Epithelial Carcinoma A549 Cells(Molecular and Cell Biology)
- The Anti-apoptotic and Anti-oxidant Effect of Eriodictyol on UV-Induced Apoptosis in Keratinocytes(Molecular and Cell Biology)
- Highly Porous Organic Nanoparticles Formed from Supercritical Carbon Dioxide Mediated Sol-Emulsion-Gel Method
- Resveratrol Enhances 5-Hydroxytryptamine Type 3A Receptor-Mediated Ion Currents: The Role of Arginine 222 Residue in Pre-transmembrane Domain I
- Effects of Quercetin on Human α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor-Mediated Ion Currents
- Propagation of a Light-Emitting Wave-Front in a Fine Tube Positive Column Discharge
- Altered Gene Expression Profiles in Mouse Tetraploid Blastocysts
- Chemopreventive Effects of Rubus coreanus Miquel on Prostate Cancer