Metabolism of Ginsenoside R_c by Human Intestinal Bacteria and Its Related Antialiergic Activity
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概要
- 論文の詳細を見る
When ginsenoside R_c was anaerobically incubated with human fecal microflora, all specimens metabolized ginsenoside R_c to compound K and protopanaxadiol. The main metabolite was compound K. Among the bacteria isolated from human fecal microflora, most bacteria, such as Bacteroides sp., Eubacterium sp., and Bifidobacterium sp. potently transformed ginsenoside R_c to compound K. Bifidobacterium K-103 and Eubacterium A-44 transformed it to compound K via ginsenoside R_d, and Bacteroides HJ-15 and Bifidobacterium K-506 metabolized to compound K via ginsenoside Mb, which was isolated as a new metabolite (M.W. 940[+Na]). Among ginsenoside R_c and its metabolites, compound K exhibited the most potent antiallergic activity on the IgE-induced RBL cell line as well as potent cytotoxic activity against tumor cell lines.
- 社団法人日本薬学会の論文
- 2002-06-01
著者
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Shin Yong
College Of Pharmacy Kyung Hee University
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Kim Dong-hyun
College Of Pharmacy Kyung Hee University
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BAE Eun-Ah
College of Pharmacy, Kyung Hee University
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PARK Eun-Kyung
College of Pharmacy, Kyung Hee University
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CHOO Min-Kyung
College of Pharmacy, Kyung Hee University
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PARK Sun-Young
College of Pharmacy, Kyung Hee University
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SHIN Ho-Young
College of Pharmacy, Kyung Hee University
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Bae Eun-ah
韓国
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Bae Eun-ah
College Of Pharmacy Kyung Hee University
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Park Eun-kyung
韓国
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Park Eun-kyung
College Of Pharmacy Kyung Hee University
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Park Eun
Department Of Biochemistry Kon Kuk University
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Park Sun-young
College Of Pharmacy Kyung Hee University
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Park Sun-young
韓国
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Kim Deog
College Of Pharmacy Kyung Hee University
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Choo Min-kyung
College Of Pharmacy Kyung Hee University
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Choo Min-kyung
韓国
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Kim D‐h
College Of Pharmacy Kyung Hee University
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Bae E‐a
College Of Pharmacy Kyung Hee University
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Park S‐y
College Of Pharmacy Kyung Hee University
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Park E‐k
College Of Pharmacy Kyung Hee University
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Park S‐y
Korea Res. Inst. Biosci. And Biotechnol. Taejon Kor
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Bae Eun-ah
Department Of Life And Nanopharmaceutical Sciences And Department Of Pharmaceutical Science Kyung He
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Han Myung
Dep. Of Food And Nutrition Kyung Hee Univ.
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Kim Dong-hyun
Department Of Life And Nanopharmaceutical Sciences And Department Of Pharmaceutical Science Kyung He
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Park Sun-young
College Of Pharmacy Kyung-hee University
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Kim D‐h
Taegu Univ. Kyungbuk Kor
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Shin Ho-young
韓国
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Shin Ho-young
College Of Pharmacy Kyung Hee University
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Shin H‐y
Kyung Hee Univ. Seoul Kor
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Kim Dong-hyun
College Of Pharmacy
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