Anti-inflammatory Activity of Gumiganghwaltang through the Inhibition of Nuclear Factor-κB Activation in Peritoneal Macrophages(Pharmacology)
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概要
- 論文の詳細を見る
Gumiganghwaltang (GMGHT) is an Oriental herbal prescription, which has been commonly used to treat a cold and inflammatory diseases in Korea. However, the mechanism of GMGHT is not clear. In this study, we investigated the anti-inflammatory mechanism of GMGHT in mouse peritoneal macrophages. GMGHT exerted an anti-inflammatory action through inhibiting lipopolysaccaride (LPS)-induced tumor necrosis factor (TNF)-α and interleukin (IL)-6 production in mouse peritoneal macrophages. The maximal inhibition rate of TNF-α, and IL-6 production by GMGHT (1 mg/ml) was 52.31±2.8% and 56.31±3.1%, respectively. In the inflammatory process, cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) increased in peritoneal macrophages. GMGHT decreased the protein level of COX-2 and iNOS in LPS-stimulated mouse peritoneal macrophages. In addition, GMGHT inhibited nuclear factor-κβ activation and Iκβ-α degradation. Our study suggests that an important molecular mechanism by GMKHT reduce inflammation, which might explain its beneficial effect in the regulation of inflammatory reactions.
- 社団法人日本薬学会の論文
- 2005-02-01
著者
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Jung Hyuk-sang
Biochip Research Center Hoseo University
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Kim Hyung-min
College Of Oriental Medicine Kyung Hee University
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Jeong Hyun-ja
Dep. Of Anatomy School Of Medicine Chonbuk National Univ.
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Yang Deok-chun
韓国
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Yang Deok-chun
Department Of Oriental Medicine Material And Processing Kyung Hee University
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Hong Seung-Heon
College of Pharmacy, VCRC of Wonkwang University
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Kim Sung-hoon
韓国
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Moon Phil-dong
College Of Oriental Medicine Kyung Hee University
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Moon Phil-dong
College Of Pharmacy Wonkwang University
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Kim Su-jin
Vestibulocochlear Research Center Of Wonkwang University:college Of Oriental Medicine Kyung Hee Univ
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Hong Seung-heon
Vestibulocochlear Research Center Of Wonkwang University
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Hong S‐h
韓国
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Hong Seung-heon
韓国
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Hong Seung-heon
Department Of Oriental Pharmacy College Of Pharmacy Wonkwang University
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Na Ho-jeong
韓国
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KIM Su-Jin
College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University
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JEONG Hyun-Ja
College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University
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LEE Kang-Min
Division of Biological Sciences, College of Natural Science, Chonbuk National University
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LEE Hong-Beom
College of Oriental Medicine, Kyung Hee University
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JUNG Hee-Jae
College of Oriental Medicine, Kyung Hee University
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JUNG Sung-Ki
College of Oriental Medicine, Kyung Hee University
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RHEE Hyung-Koo
College of Oriental Medicine, Kyung Hee University
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Kim Hyung-min
韓国
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Jeong H‐j
Dep. Of Oriental Pharmacy Wonkwang Univ.
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Lee K‐m
Division Of Biological Sciences College Of Natural Science Chonbuk National University
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Kim Sung‐hoon
韓国
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Jung H‐s
Division In Anatomy And Developmental Biology Department Of Oral Biology College Of Dentistry Yonsei
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Kim Su-jin
Division Of Environmental Science And Technology Graduate School Of Agriculture
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Kim H‐m
Kyung Hee Univ. Seoul Kor
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Kim Hyung
College Of Oriental Medicine Kyung Hee University
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Jung S‐k
Kyunghee Univ. Seoul Kor
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Lee Hong-beom
Division Of Ocean Science Korea Maritime University
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Jung Hyuk-sang
Department Of Anatomy College Of Oriental Medicine Kyung Hee University
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Na Ho‐jeong
College Of Pharmacy Wonkwang University
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KIM Sung-Hoon
Toxicology Research Center Korea Research Institute of Chemical Technology
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Kim Hyung‐min
Dep. Of Anatomy School Of Medicine Chonbuk National Univ.
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Kim Hyung-ryong
Dep. Of Dental Pharmacology And Wonkwang Biomaterial Implant Res. Inst. School Of Dentistry Wonkwang
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Kim H.
韓国
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Kim H‐m
Yonsei Univ. School Of Medicine
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Kim Seung-ae
Cancer Preventive Material Dev. Res. Center Coll. Of Oriental Medicine Kyunghee Univ.
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Lee Hyo-jung
Coll. Of Oriental Medicine Kyung Hee Univ.
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Kim Sung-hoon
Coll. Of Oriental Medicine Kyung Hee Univ.
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Lee Kang-min
Division Of Biological Sciences College Of Natural Science Chonbuk National University
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Na Ho‐jeong
韓国
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Jung Hyun-ju
Coll. Of Pharmacy And Wonkwang-oriental Medicines Res. Inst. Wonkwang Univ.
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So Hong-seob
韓国
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Rhee Hyung-koo
College Of Oriental Medicine Kyung Hee University
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Jung H‐a
Coll. Of Oriental Medicine And Inst. Of Oriental Medicine Kyung Hee Univ.
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Na Ho‐jeong
Dep. Of Pharmacology Coll. Of Oriental Medicine Inst. Of Oriental Medicine Kyung Hee Univ.
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Kim Hong‐joon
Department Of Veterinary Medicine College Of Life Sciences Research Institute For Subtropical Agricu
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Yang Deok-chun
Department Of Oriental Medical Materials And Processing Kyung-hee University
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Shin H‐y
Kyung Hee Univ. Seoul Kor
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Jeong Hyun-Ja
College of Oriental Medicine and Institute of Oriental Medicine, Kyung Hee University
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