クリップ圧迫により損傷したラット脊髄におけるオステオポンティンの免疫組織化学的研究(短報)(病理学)
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概要
- 論文の詳細を見る
オステオポンティン(osteopontin, OPN)の発現をクリップ圧迫により損傷させたラットの脊髄で調べた.ウェスタンブロットによる分析では,脊髄損傷後の初期段階でOPN蛋白が有意に上昇した.OPN発現の増加は増殖細胞核抗原(PCNA)の発現増加と一部相関していた.免疫染色ではOPNは病巣中心部で増殖し活性化したミクログリア/マクロファージで発現し,病巣周辺のアストロサイトの一部でも陽性であった.これらの結果はOPN蛋白の発現が脊髄損傷後は主に活性化したミクログリア/マクロファージで増殖することを示し,0PNが損傷初期のおそらく組織改築に導く細胞増殖に関与することを示唆する.
- 社団法人日本獣医学会の論文
- 2004-10-25
著者
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Kim Hyung
Department of Internal Medicine, Seoul National University College of Medicine, Cardiovascular Labor
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Kim Sung
韓国
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Na Ho-jeong
韓国
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SHIN Taekyun
Department of Veterinary Medicine, Graduate School, Cheju National University
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AHN Meejung
Department of Veterinary Medicine, Graduate School, Cheju National University
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KIM Heechul
Department of Veterinary Medicine, Graduate School, Cheju National University
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MOON Changjong
Department of Veterinary Medicine, College of Applied Life Science and Applied Radiological Science
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Kim Hyung
Department Of Biochemistry Ewha Womans University School Of Medicine
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Kim H‐m
Kyung Hee Univ. Seoul Kor
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Kim Hyung
College Of Oriental Medicine Kyung Hee University
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Kim Hyung-ryong
Dep. Of Dental Pharmacology And Wonkwang Biomaterial Implant Res. Inst. School Of Dentistry Wonkwang
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Kim H.
韓国
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HEO Seungdam
Department of Veterinary Medicine, College of Agriculture and Life Sciences, Cheju National Universi
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SHIN Myungseung
Department of Veterinary Medicine, College of Agriculture and Life Sciences, Cheju National Universi
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SIM Ki
Department of Neurosurgery, College of Medicine, Cheju National University
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Kim Seungjoon
Department Of Veterinary Anatomy College Of Veterinary Medicine Chonnam National University
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Kim Sung-ho
Department Of Internal Medicine College Of Veterinary Medicine Seoul National University
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Sim Ki
Department Of Neurosurgery College Of Medicine Cheju National University
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Na Ho‐jeong
韓国
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Kang Seong
Department Of Veterinary Surgery College Of Veterinary Medicine Chonnam National University
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Shin Myungseung
Department Of Molecular Biology College Of Natural Science Pusan National University
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Ahn Meejung
Department Of Veterinary Anatomy College Of Veterinary Medicine And Research Institute For Subtropic
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Heo Seungdam
Department Of Veterinary Medicine College Of Agriculture And Life Sciences Cheju National University
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Shin Taekyun
Jeju National Univ. Jeju
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Shin Taekyun
Department Of Veterinary Medicine Cheju National University
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Moon C
Department Of Veterinary Anatomy College Of Veterinary Medicine Chonnam National University
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Moon Changjong
Department Of Physiology University Of The Ryukyus School Of Medicine:department Of Veterinary Medic
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Jung H‐a
Coll. Of Oriental Medicine And Inst. Of Oriental Medicine Kyung Hee Univ.
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Na Ho‐jeong
Dep. Of Pharmacology Coll. Of Oriental Medicine Inst. Of Oriental Medicine Kyung Hee Univ.
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Kim Hong‐joon
Department Of Veterinary Medicine College Of Life Sciences Research Institute For Subtropical Agricu
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Shin T
Jeju National Univ. Jeju
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Shin Taekyun
Department of Veterinary Anatomy, College of Veterinary Medicine and Research Institute for Subtropical Agriculture and Biotechnology, Cheju National University
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SHIN Taekyun
Department of Veterinary Anatomy, College of Veterinary Medicine and Applied Radiological Science Research Institute, Jeju National University
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