The Oriental Medicine 'Cool-Cool (Cool-X-A)' Inhibits Inflammatory Cytokine Production and Migration in Mast Cells(Pharmacology)

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概要

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• Plant medications have been applied to treat pains from various types of arthritis in Korea. Rheumatoid arthritis (RA) is well known to be a chronic autoimmune/inflammatory disease that leads to progressive joint damage and cartilage destruction. Accumulation and activation of mast cells have been demonstrated in rheumatoid synovial tissue. Because infiltrated mast cells and their mediators may contribute to the initiation and progression of the inflammatory process and matrix degradation of RA, we tested the inhibitory effects of 'Cool-Cool' (CC, Cool-X-A), an Oriental medication, on the production and migration of major inflammatory cytokines in mast cells. CC was treated in vitro before activation of human mast cell line (HMC-1) with phorbol 12-myristate 13-acetate, and the cytotoxicity of CC was assessed by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazoliumbromide assay. CC had no cytotoxic effects on HMC-1 cell viability. The inhibitory effects on cytokine production were monitored by enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction (RT-PCR). CC inhibited not only the secretion but also the expression of TNF-α and IL-8 in HMC-1 cells. CC also suppressed migration of mast cells induced by stem cell factor. These findings may help in understanding the mechanism of action of this herbal medication, leading to the control of mast cells in inflammatory conditions like RA.

• 公益社団法人日本薬学会の論文
• 2004-01-01

著者

• Jeong Hyun-ja

  Dep. Of Anatomy School Of Medicine Chonbuk National Univ.

• Shin Tae

  Department Of Veterinary Medicine Institute For Life Science Cheju National University

• Kim Hyung-Min

  Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee

• Hong Seung-heon

  Vestibulocochlear Research Center Of Wonkwang University

• Hong S‐h

  韓国

• Hong Seung-heon

  韓国

• Hong Seung-heon

  Department Of Oriental Pharmacy College Of Pharmacy Wonkwang University

• Na Ho-jeong

  韓国

• CHOI In-Young

  VestibuloCochlear Research Center of Wonkwang University

• KIM Mi-Sun

  Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University

• Kim Hyung-min

  韓国

• SHIN Taekyun

  Department of Veterinary Medicine, Graduate School, Cheju National University

• Shin T

  韓国

• CHOI In-Young

  Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University

• Jung H‐s

  Division In Anatomy And Developmental Biology Department Of Oral Biology College Of Dentistry Yonsei

• Kim M‐s

  Vestibulocochlear Research Center Of Wonkwang University

• Kim H‐m

  Kyung Hee Univ. Seoul Kor

• Kim Hyung

  College Of Oriental Medicine Kyung Hee University

• Kim Hyung-min

  Department Of Pharmacology College Of Oriental Medicine Kyung Hee University

• Kim Mi-sun

  College Of Pharmacy Wonkwang University

• Jung Hyuk-sang

  Department Of Anatomy College Of Oriental Medicine Kyung Hee University

• Na Ho‐jeong

  College Of Pharmacy Wonkwang University

• Kim Hyung‐min

  Dep. Of Anatomy School Of Medicine Chonbuk National Univ.

• Kim Hyung-ryong

  Dep. Of Dental Pharmacology And Wonkwang Biomaterial Implant Res. Inst. School Of Dentistry Wonkwang

• Kim H.

  韓国

• Kim H‐m

  Yonsei Univ. School Of Medicine

• LEE Si-Hyeong

  College of Oriental Medicine, Wonkwang University

• Lee Si-hyeong

  College Of Oriental Medicine Wonkwang University

• Na Ho‐jeong

  韓国

• So Hong-seob

  韓国

• Shin Taekyun

  Department Of Veterinary Medicine Cheju National University

• Jung H‐a

  Coll. Of Oriental Medicine And Inst. Of Oriental Medicine Kyung Hee Univ.

• Na Ho‐jeong

  Dep. Of Pharmacology Coll. Of Oriental Medicine Inst. Of Oriental Medicine Kyung Hee Univ.

• Kim Hong‐joon

  Department Of Veterinary Medicine College Of Life Sciences Research Institute For Subtropical Agricu

• Kim Mi-sun

  Department Of Dermatology Seoul National University College Of Medicine

• Shin H‐y

  Kyung Hee Univ. Seoul Kor

• Shin Taekyun

  Department of Veterinary Anatomy, College of Veterinary Medicine and Research Institute for Subtropical Agriculture and Biotechnology, Cheju National University

• SHIN Taekyun

  Department of Veterinary Anatomy, College of Veterinary Medicine and Applied Radiological Science Research Institute, Jeju National University

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