Antinociceptive Anti-inflammatory Effect of Monotropein Isolated from the Root of Morinda officinalis(Pharmacognosy)
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概要
- 論文の詳細を見る
The root of Morinda officinalis (Rubiaceae) is used to treat rheumatoid arthritis and impotence in the traditional Oriental medicine. To identify the antinociceptive anti-inflammatory components of this crude drug, we adopted an activity-directed fractionation approach. The active fraction of the BuOH extract of M. officinalis root was subjected to silica gel and ODS column chromatography to yield two diterpenes, compounds 1 and 2 and these were identified as monotropein and deacetylasperulosidic acid, respectively. The iridoid glycoside, monotropein, was tested for its anti-inflammatory antinociceptive effects using hot plate- and writhing antinociceptive assays and by using carrageenan-induced anti-inflammatory assays in mice and rats. Pretreatment with monotropein (at 20, 30mg/kg/d, p.o.) significantly reduced stretching episodes and prolonged action time in mice. It also significantly reduced acute paw edema by carrageenan in rats. These results indicate that monotropein contributes to the antinociceptive and anti-inflammatory action of Morinda officinalis root.
- 社団法人日本薬学会の論文
- 2005-10-01
著者
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LEE Kyung-Tae
College of Pharmacy, Kyung-Hee University
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Choi Jongwon
Coll. Of Pharmacy Kyungsung Univ.
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Choi Jong-won
韓国
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Choi Jong-won
College Of Pharmacy Kyung-sung University
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Lee Kyung-tae
College Of Pharmacy Kyung-hee University
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Lee Kyung-tae
Coll. Of Medical Sci. Kyung Hee Univ.
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Lee Kyung
College Of Pharmacy Dongdaemun-ku Hoegi-dong Kyung-hee University
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Park Hee-juhn
Department Of Pharmaceutical Engineering Sangji University
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Park Hee-juhn
韓国
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Park Hee-juhn
Division Of Applied Plant Sciences Sangji University
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Park Hee
Department Of Botanical Resources Sangji University
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Park Hee-juhn
Department Of Botanical Resources Sangi University
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CHOI Jongwon
College of Pharmacy, Kyungsung University
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Jeong H‐j
Dep. Of Oriental Pharmacy Wonkwang Univ.
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Lee Kyung-tae
Department Of Pharmacological Biochemistry College Of Pharmacy Kyung Hee University
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CHOI Moo
Department of Food and Nutrition, Sangji University
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NAM Jung
Department of Botanical Resources, Sangji University
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JUNG Hyun
Department of Botanical Resources, Sangji University
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PARK Sun
Department of Botanical Resources, Sangji University
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Nam Jung-hwan
韓国
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Nam Jung-hwan
Highland Agriculture Institute Rural Development Administration
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Choi Jong-won
Coll. Of Pharmacy Kyungsung Univ.
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Park Sun
Department Of Agricultural Chemistry The University Of Tokyo
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Choi Jung-hye
Department Of Internal Medicine Hanyang University
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Choi Moo-young
Department Of Agricultural Chemistry Faculty Of Agriculture Kyushu University
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Choi Moo
Department Of Food And Nutrition Sangji University
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Jung Hyuk-sang
Department Of Anatomy College Of Oriental Medicine Kyung Hee University
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Lee Kyung
Department Of Biochemistry College Of Pharmacy Kyung-hee University
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Park Hee-joun
Department Of Botanical Resources Sangji University
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Choi Jongwon
College Of Pharmacy Daeyeon-dong Kyungsung University
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Jung Hyun-ju
Coll. Of Pharmacy And Wonkwang-oriental Medicines Res. Inst. Wonkwang Univ.
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Choi Jung-hye
Dep. Of Oriental Pharmaceutical Sci. Coll. Of Pharmacy Kyung Hee Univ.
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Park Sun
Department Of Botanical Resources Sangji University
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Choi Jeongeun
College Of Pharmacy Kyungsung University
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Park Hee
Department Of Biology College Of Natural Sciences Kyungpook National University Korea
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PARK Hee
Department of Anesthesiology and Pain Medicine, Gil Medical Center, Gachon University
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