In Vitro Antiinflammatory Activity of Kalopanaxsaponin A Isolated from Kalopanax pictus in Murine Macrophage RAW 264.7 Cells

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概要

• 論文の詳細を見る

• In the present study, effects of various hederagenin monodesmosides isolated from the stem bark of Kalopanax pictus NAKAI, such as hederagenin, δ-hederin, kalopanaxsaponin A, kalopanaxsaponin I, and sapindoside C, have been evaluated on lipopolysaccharide (LPS)-induced nitric oxide (NO), prostaglandin E_2 (PGE_2) and tumor necrosis factor-α (TNF-α) release by the macrophage cell line RAW 264.7. Among the tested monodesmosides, kalopanxsaponin A was the most potent inhibitor of NO production, and it also significantly decreased PGE_2 and TNF-α release. Consistent with these observations, the expression level of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 enzyme was inhibited by kalopanxsaponin A in a concentration-dependent manner. Thus, this study suggests that kalopanaxsaponin A-mediated inhibition of iNOS, COX-2 expression, and TNF-α release may be one of the mechanisms responsible for the anti-inflammatory effects of the stem bark of Kalopanaxpictus NAKAI.

• 社団法人日本薬学会の論文
• 2002-04-01

著者

• PARK Hee-Juhn

  Division of Applied Plant Sciences, Sang-Ji University

• LEE Kyung-Tae

  College of Pharmacy, Kyung-Hee University

• CHOI Jong-Won

  College of Pharmacy, Kyung-Sung University

• Choi Jongwon

  Coll. Of Pharmacy Kyungsung Univ.

• Choi Jong-won

  韓国

• Choi Jong-won

  College Of Pharmacy Kyung-sung University

• Kim You-ah

  Div. Of Marine Environment & Bioscience Korea Maritime Univ.

• Lee Kyung-tae

  韓国

• Lee Kyung-tae

  College Of Pharmacy Kyung-hee University

• Lee Kyung-tae

  Coll. Of Pharmacy Kyung-hee Univerisity

• Lee Kyung-tae

  Department Of Life And Nanopharmaceutical Sciences College Of Pharmacy Kyung Hee University

• Lee Kyung-tae

  Coll. Of Medical Sci. Kyung Hee Univ.

• Park Hee-juhn

  Department Of Pharmaceutical Engineering Sangji University

• Park Hee-juhn

  韓国

• Park Hee-juhn

  Division Of Applied Plant Sciences Sangji University

• Park Hee-juhn

  Department Of Botanical Resources Sangi University

• Ryu Jong

  Department Of Life And Nanopharmaceutical Sciences College Of Pharmacy Kyung Hee University

• KIM Rung-Gyu

  College of Pharmacy, Kyung-Hee University

• KIM Young-Kwan

  College of Pharmacy, Kyung-Hee University

• KIM Ryung-Gue

  College of Pharmacy, Kyung-Hee University

• PARK So-Jung

  College of Pharmacy, Kyung-Hee University

• HA Joo-Hun

  Medicine, Kyung-Hee University

• Lee Kyung

  College Of Pharmacy Kyung Hee University

• Lee Kyung-won

  韓国

• Lee Kyung‐won

  Kyung Hee Univ. Seoul Kor

• Kim Yun-kyung

  Department Of Oriental Pharmacy College Of Pharmacy Wonkwang University

• Kim You-ah

  韓国

• Kim Y‐k

  Wonkwang Univ. Jeonbuk Kor

• Ryu Jong

  Department Of Oriental Pharmaceutical Science Kyunghee University

• Choi Jong-won

  Coll. Of Pharmacy Kyungsung Univ.

• Choi Jung-hye

  Department Of Internal Medicine Hanyang University

• Park So-jung

  College Of Pharmacy Kyung-hee University

• Park Hee-joun

  Department Of Botanical Resources Sangji University

• Choi Jung-hye

  Dep. Of Oriental Pharmaceutical Sci. Coll. Of Pharmacy Kyung Hee Univ.

• Choi Jeongeun

  College Of Pharmacy Kyungsung University

• Kim Rung-gyu

  College Of Pharmacy Kyung-hee University

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