Effects of Dietary Supplementation of Lipophilic Fraction from Panax ginseng on cGMP and cAMP in Rat Platelets and on Blood Coagulation
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概要
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We have studied the effect of dietary supplementation with 25 mg (0.0025% of the total diet) of a lipophilic fraction (LF) from Panax ginseng on rat platelet aggregation induced by collagen or thrombin, and on blood coagulation.When platelets prepared from 15% corn oil plus LF-administered rats (COLF) were stimulated by thrombin (0.1 units/ml) and collagen (100 μg/ml), the cGMP level was significantly increased as compared with those from 15% corn oil only-administered rats (CO). The levels of cAMP in COLF were decreased by thrombin, but was increased by collagen. Furthermore, the levels of both cGMP and cAMP were also increased by the exogenous addition of LF to thrombin- and collagen-stimulated platelets. These results mean that LF increases cGMP directly and cAMP indirectly, and thus inhibits thrombin- or collagen-induced rat platelet aggregation.Both the thrombin time (TT) and activated partial thromboplastin time (APTT) were prolonged more in citrated platelet-poor plasma from COLF than in that from CO. The level of lipids such as triglyceride, total cholesterol, high density liporotein-cholesterol and low density lipoprotein-cholesterol was decreased in serum from COLF more than in that of CO.Thus, these results suggest that dietary LF regulates the levels of cGMP and cAMP, and prolongs the time interval (TT, APTT) between the conversion of fibrinogen to fibrin. Accordingly, our data demonstrate that dietary LF has an antithrombotic effect in vivo.
- 公益社団法人日本薬学会の論文
- 1996-11-15
著者
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Park Hee-juhn
Division Of Applied Plant Sciences Sangji University
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Lee Jung-hee
Department Of Orthopedic Surgery School Of Medicine Pusan National University
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Park Kyeong-mee
Department Of Biochemical Pharmacology Korea Ginseng And Tobacco Research Institute
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Song Y‐b
Department Of Biomedical Pharmacology Korea Ginseng And Tobacco Research Institute
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Lee J‐h
Ewha Womans Univ. Seoul Kor
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PARK Hwa-Jin
Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, Inje Uni
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PARK Ki-Hyun
Department of Biomedical Pharmacology Korea Ginseng and Tobacco Research Institute
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Song Yong-bum
Department Of Biochemical Pharmacology Korea Ginseng And Tobacco Research Institute
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Park Hwa
Department Of Biomedical Laboratory Science College Of Biomedical Science And Engineering And Region
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Park Hwa-jin
Department Of Biochemical Pharmacology Korea Ginseng And Tobacco Research Institute
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Lee Jung-hee
Department Of Electrical Engineering Korea Advanced Institute Of Science & Technology
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Lee Jung-Hee
Department of Biochemical Pharmacology, Korea Ginseng and Tobacco Research Institute
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