19α-Hydroxyursane-Type Triterpenoids : Antinociceptive Anti-inflammatory Principles of the Roots of Rosa rugosa(Pharmacognosy)

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概要

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• To search for antiinflammtory 19α-hydroxyursane-type triterpenoids, the MeOH extract of the roots of Rosa rugosa (Rosaceae) was fractionated. The active fraction of the EtOAc extract was hydrolyzed in alkaline solution to give a hydrolyzed fraction. Both extracts showed antiinflammatory/antinociceptive action in acetic acid-induced writhing and hot plate testing and in a carrageenan-induced paw edema model in mice and rats. Repeated chromatography of the EtOAc extract on both silica gel and octadecylsilane columns led to the isolation of kaji-ichigoside F_1 (1, euscaphic acid 28-0-glucoside) and rosamultin (2, tormentic acid 28-0-glucoside). The hydrolyzed fraction was also subjected to silica gel column and octadecylsilane column chromatography to produce euscaphic acid (3) and tormentic acid (4). The potencies were observed in the following order : 4>3>2>1. These results suggest that 19α-hydroxyursane-type triterpenoids are responsible for the antiinflammatory/antinociceptive action of R. rugosa roots.

• 社団法人日本薬学会の論文
• 2005-01-01

著者

• PARK Hee-Juhn

  Division of Applied Plant Sciences, Sang-Ji University

• LEE Kyung-Tae

  College of Pharmacy, Kyung-Hee University

• Choi Jongwon

  Coll. Of Pharmacy Kyungsung Univ.

• Choi Jong-won

  韓国

• Choi Jong-won

  College Of Pharmacy Kyung-sung University

• Lee Kyung-tae

  韓国

• Lee Kyung-tae

  College Of Pharmacy Kyung-hee University

• Lee Kyung-tae

  Coll. Of Pharmacy Kyung-hee Univerisity

• Lee Kyung-tae

  Department Of Life And Nanopharmaceutical Sciences College Of Pharmacy Kyung Hee University

• Lee Kyung-tae

  Coll. Of Medical Sci. Kyung Hee Univ.

• Lee Kyung-tae

  Department Of Biochemistry College Of Pharmacy Kyung Hee University

• Park Hee-juhn

  Department Of Pharmaceutical Engineering Sangji University

• Park Hee-juhn

  韓国

• Park Hee-juhn

  Division Of Applied Plant Sciences Sangji University

• Park Hee-juhn

  Department Of Botanical Resources Sangi University

• CHOI Jongwon

  College of Pharmacy, Kyungsung University

• JUNG Hyun-Ju

  Division of Applied Plant Sciences, Sangji University

• NAM Jung-Hwan

  Division of Applied Plant Sciences, Sangji University

• Jeong H‐j

  Dep. Of Oriental Pharmacy Wonkwang Univ.

• Lee Kyung

  College Of Pharmacy Kyung Hee University

• Lee Kyung-won

  韓国

• Lee Kyung‐won

  Kyung Hee Univ. Seoul Kor

• Nam Jung-hwan

  韓国

• Nam Jung-hwan

  Highland Agriculture Institute Rural Development Administration

• Choi Jong-won

  Coll. Of Pharmacy Kyungsung Univ.

• Choi Jung-hye

  Department Of Internal Medicine Hanyang University

• Jung Hyuk-sang

  Department Of Anatomy College Of Oriental Medicine Kyung Hee University

• Park Hee-joun

  Department Of Botanical Resources Sangji University

• Choi Jongwon

  College Of Pharmacy Daeyeon-dong Kyungsung University

• Jung Hyun-ju

  Coll. Of Pharmacy And Wonkwang-oriental Medicines Res. Inst. Wonkwang Univ.

• Choi Jung-hye

  Dep. Of Oriental Pharmaceutical Sci. Coll. Of Pharmacy Kyung Hee Univ.

• Choi Jeongeun

  College Of Pharmacy Kyungsung University

• Nam JungHwan

  Division of Applied Plant Sciences, Sangji University

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