Fimasartan, Anti-hypertension Drug, Suppressed Inducible Nitric Oxide Synthase Expressions via Nuclear Factor-Kappa B and Activator Protein-1 Inactivation
スポンサーリンク
概要
- 論文の詳細を見る
Since inhibition of angiotensin II type 1 (AT1) receptor reduces chronic inflammation associated with hypertension, we evaluated the anti-inflammatory potential and the underlying mechanism of fimasartan, a Korean Food and Drug Administration approved anti-hypertension drug, in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Fimasartan suppressed the expressions of inducible nitric oxide synthase (iNOS) by down-regulating its transcription, and subsequently inhibited the productions of nitric oxide (NO). In addition, fimasartan attenuated LPS-induced transcriptional and DNA-binding activities of nuclear factor-kappa B (NF-κB) and activator protein-1 (AP-1). These reductions were accompanied by parallel reductions in the nuclear translocation of NF-κB and AP-1. Taken together, our data suggest that fimasartan down-regulates the expression of the iNOS in macrophages via NF-κB and AP-1 inactivation.
- 公益社団法人 日本薬学会の論文
著者
-
Lee Kyung-tae
Department Of Biochemistry College Of Pharmacy Kyung Hee University
-
Cho Young-wuk
Department Of Physiology College Of Medicine Kyung Hee University
-
Shin Ji-sun
Department Of Pediatric Dentistry Dental Hospital Dankook University
-
Lee Joo
Central Research Institute, Boryung Pharm. Co., Ltd.
-
Ryu Suran
Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University
-
Kim Hyoung
Central Research Institute, Boryung Pharm. Co., Ltd.
-
Paik Soo
Central Research Institute, Boryung Pharm. Co., Ltd.
-
Chi Yong
Central Research Institute, Boryung Pharm. Co., Ltd.
-
Kim Ji
Central Research Institute, Boryung Pharm. Co., Ltd.
-
Kim Je
Central Research Institute, Boryung Pharm. Co., Ltd.
-
Lee Kyung-Tae
Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University
-
Cho Young-Wuk
Department of Biomedical Science, College of Medical Science, Kyung Hee University
-
Shin Ji-Sun
Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University
関連論文
- 3α,23-Isopropylidenedioxyolean-12-en-27-oic Acid, a Triterpene Isolated from Aceriphyllum rossii, Induces Apoptosis in Human Cervical Cancer HeLa Cells through Mitochondrial Dysfunction and Endoplasmic Reticulum Stress
- Taraxinic Acid, a Hydrolysate of Sesquiterpene Lactone Glycoside from the Taraxacum coreanum NAKAI, Induces the Differentiation of Human Acute Promyelocytic Leukemia HL-60 Cells
- Preventive Effect of Ginkgo biloba Extract (GBB) on the Lipopolysaccharide-Induced Expressions of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 via Suppression of Nuclear Factor-κB in RAW 264.7 Cells(Pharmacognosy)
- The Anti-gastropathic and Anti-rheumatic Effect of Niga-ichigoside F_1 and 23-Hydroxytormentic Acid Isolated from the Unripe Fruits of Rubus coreanus in a Rat Model(Pharmacognosy)
- β-D-Xylopyranosyl-(1→3)-β-D-glucuronopyranosyl Echinocystic Acid Isolated from the Roots of Codonopsis lanceolata Induces Caspase-Dependent Apoptosis in Human Acute Promyelocytic Leukemia HL-60 Cells(Pharmacognosy)
- 19α-Hydroxyursane-Type Triterpenoids : Antinociceptive Anti-inflammatory Principles of the Roots of Rosa rugosa(Pharmacognosy)
- Methanol Extract of Xanthium strumarium L. Possesses Anti-inflammatory and Anti-nociceptive Activities(Pharmacognosy)
- Saucernetin-8 Isolated from Saururus chinensis Induced the Differentiation of Human Acute Promyelocytic Leukemia HL-60 Cells(Pharmacognosy)
- Anti-inflammatory and Anti-nociceptive Effects of the Methanol Extract of Fomes fomentarius(Pharmacognosy)
- Structure-Activity Relationship of Oleanane Disaccharides Isolated from Akebia quinata versus Cytotoxicity against Cancer Cells and NO Inhibition (Pharmacognosy)
- Inhibition of Methanol Extract from the Fruits of Kochia scoparia on Lipopolysaccharide-Induced Nitric Oxide, Prostagladin E_2, and Tumor Necrosis Factor-α Production from Murine Macrophage RAW 264.7 Cells (Pharmacognosy)
- Antinociceptive and Antiinflammatory Effects of Niga-ichigoside F_1 and 23-Hydroxytormentic Acid Obtained from Rubus coreanus(Pharmacognosy)
- Inhibition of Methanol Extract from the Aerial Parts of Saururus chinensis on Lipopolysaccharide-Induced Nitric Oxide and Prostagladin E_2 Production from Murine Macrophage RAW 264.7 Cells
- Costunolide Triggers Apoptosis in Human Leukemia U937 Cells by Depleting Intracellular Thiols
- A Cytotoxic and Apoptosis-Inducing Sesquiterpenoid Isolated from the Aerial Parts of Artemisia princeps PAMPANINI (Sajabalssuk)
- Protective Effect of the Ethanol Extract of the Roots of Brassica rapa on Cisplatin-Induced Nephrotoxicity in LLC-PK_1 Cells and Rats(Pharmacognosy)
- Induction of Apoptosis by Yomogin in Human Promyelocytic Leukemic HL-60 Cells(Pharmacognosy)
- Inhibition of LPS-Induced iNOS, COX-2 and Cytokines Expression by Poncirin through the NF-κB Inactivation in RAW 264.7 Macrophage Cells(Pharmacognosy)
- The Seed Extract of Cassia obtusifolia Ameliorates Learning and Memory Impairments Induced by Scopolamine or Transient Cerebral Hypoperfusion in Mice
- Lupane Glycosides from the Leaves of Acanthopanax koreanum
- Styraxoside A Isolated from the Stem Bark of Styrax japonica Inhibits Lipopolysaccharide-Induced Expression of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 in RAW 264.7 Cells by Suppressing Nuclear Factor-kappa B Activation(Pharmacognosy)
- Gluco-obtusifolin and Its Aglycon, Obtusifolin, Attenuate Scopolamine-Induced Memory Impairment
- Opioid inhibition of GABAergic neurotransmission in mechanically isolated rat periaqueductal gray neurons
- Saucernetin-7 Isolated from Saururus chinensis Induces Caspase-Dependent Apoptosis in Human Promyelocytic Leukemia HL-60 Cells(Pharmacognosy)
- Development of a liquid chromatography/negative-ion electrospray tandem mass spectrometry assay for the determination of cilnidipine in human plasma and its application to a bioequivalence study
- Development and validation of a high-performance liquid chromatography-tandem mass spectrometry for the determination of penciclovir in human plasma : Application to a bioequivalence study
- An optimized analytical method of fluconazole in human plasma by high-performance liquid chromatography with ultraviolet detection and its application to a bioequivalence study
- Costunolide-Induced Apoptosis in Human Leukemia Cells: Involvement of c-Jun N-Terminal Kinase Activation
- Costunolide Induces Apoptosis in Human Endometriotic Cells through Inhibition of the Prosurvival Akt and Nuclear Factor Kappa B Signaling Pathway
- Fraxinellone Inhibits Lipopolysaccharide-Induced Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Expression by Negatively Regulating Nuclear Factor-kappa B in RAW 264.7 Macrophages Cells
- 23-Hydroxytormentic Acid and Niga-Ichgoside F1 Isolated from Rubus coreanus Attenuate Cisplatin-Induced Cytotoxicity by Reducing Oxidative Stress in Renal Epithelial LLC-PK1 Cells
- Development and validation of a high performance liquid chromatography-tandem mass spectrometry for the determination of etodolac in human plasma
- Quantification of roxatidine in human plasma by liquid chromatography electrospray ionization tandem mass spectrometry : Application to a bioequivalence study
- Pulsus paradoxus during extraction of impacted tooth under intravenous sedation
- The Ameliorative Effect of 23-Hydroxytormentic Acid Isolated from Rubus coreanus on Cisplatin-Induced Nephrotoxicity in Rats
- Pharmacological Characterization of BR-A-657, a Highly Potent Nonpeptide Angiotensin II Receptor Antagonist
- Fimasartan, Anti-hypertension Drug, Suppressed Inducible Nitric Oxide Synthase Expressions via Nuclear Factor-Kappa B and Activator Protein-1 Inactivation