23-Hydroxytormentic Acid and Niga-Ichgoside F1 Isolated from Rubus coreanus Attenuate Cisplatin-Induced Cytotoxicity by Reducing Oxidative Stress in Renal Epithelial LLC-PK1 Cells

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概要

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• The unripe fruits of Rubus coreanus (Rosaceae) are used in traditional Chinese medicine to relieve kidney dysfunction. In the present study, we evaluated the protective effects of the triterpenoid glycoside niga-ichigoside F1 (NIF1) and of its aglycone 23-hydroxytormentic acid (23-HTA) isolated from the unripe fruits of Rubus coreanus (Rosaceae) against cisplatin-induced cytotoxicity in renal epithelial LLC-PK1 cells. Pretreating LLC-PK1 cells with 23-HTA or NIF1 was found to prevent cisplatin-induced cytotoxicity and apoptosis. In addition, 23-HTA or NIF1 pretreatment significantly improved the changes associated with cisplatin toxicity by increasing levels of glutathione (GSH) and decreasing levels of malondialdehyde (MDA) and reactive oxygen species (ROS). The activity of antioxidant enzymes including catalase (CAT) and superoxide dismutase (SOD) was significantly lower in cisplatin-treated LL-PK1 cells, and 23-HTA or NIF1 treatment notably increased the these enzyme activity and protein and mRNA levels of CAT and manganese SOD (MnSOD). Moreover, cisplatin caused a significant decrease in nuclear levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and pretreatment with 23-HTA or NIF1 significantly suppressed the cisplatin-induced translocation of Nrf2 in LLC-PK1 cells. Taken together, these results suggest that 23-HTA ameliorates cisplatin-induced toxicity via modulation of antioxidant enzymes through activation of Nrf2 in LLC-PK1 cells.

著者

• PARK Hee-Juhn

  Department of Botanical Resources, Sangji University

• Rim Hong-Kun

  Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee

• CHOI Jong-Won

  College of Pharmacy, Kyung-Sung University

• Choi Jongwon

  Coll. Of Pharmacy Kyungsung Univ.

• Choi Jong-won

  College Of Pharmacy Kyung-sung University

• Rim Hong-kun

  Dep. Of Pharmacology Coll. Of Oriental Medicine Inst. Of Oriental Medicine Kyung Hee Univ.

• Lee Kyung-tae

  Department Of Life And Nanopharmaceutical Sciences College Of Pharmacy Kyung Hee University

• Lee Kyung-tae

  Department Of Biochemistry College Of Pharmacy Kyung Hee University

• Park Hee-juhn

  Department Of Botanical Resources Sangi University

• Kim Yun-kyung

  Department Of Oriental Pharmacy College Of Pharmacy Wonkwang University

• KIM Yang-Hee

  Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung-Hee University

• Kim You-ah

  韓国

• Kim Y‐k

  Wonkwang Univ. Jeonbuk Kor

• Choi Jong-won

  Coll. Of Pharmacy Kyungsung Univ.

• Choi Jung-hye

  Department Of Internal Medicine Hanyang University

• Choi Jeongeun

  College Of Pharmacy Kyungsung University

• Kim Yang-hee

  Department Of Pharmaceutical Biochemistry College Of Pharmacy Kyung-hee University

• Kang Hyun-Jun

  Department of Pharmaceutical Biochemistry and Department of Life and Nanopharmaceutical Science, Kyu

• Chang Sung-Goo

  Medical Science and Engineering Research Center for Bioreaction to Reactive Oxygen Species, School o

• Park Jae-Hoon

  Medical Science and Engineering Research Center for Bioreaction to Reactive Oxygen Species, School o

• Kim Soo-Dong

  Department of Urology, College of Medicine, Dong-A University

• Rim Hong-Kun

  Department of Pharmaceutical Biochemistry and Department of Life and Nanopharmaceutical Science, Kyung Hee University

• Kim Yang-Hee

  Department of Pharmaceutical Biochemistry and Department of Life and Nanopharmaceutical Science, Kyung Hee University

• Kang Hyun-Jun

  Department of Pharmaceutical Biochemistry and Department of Life and Nanopharmaceutical Science, Kyung Hee University

• Choi Jong-won

  College of Pharmacy, Kyungsung University

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