Hypericin Induces Both Differentiation and Apoptosis in Human Promyelocytic Leukemia HL-60 Cells
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概要
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Hypericin is a unique photosensitizing plant pigment and has been separately reported to induce differentiation and apotosis in neoplastic cells. In this study, we examined the relationship between activities to induce differentiation and apoptosis in human promyelocytic leukemia HL-60 cells, at a concentration range of 0.15 to 0.2μM. When treated with hypericin, the cell ratio reducible of nitroblue tetrazolium was significantly increased and the cell size was enlarged by flow cytometry analysis. Hypericin also significantly increased the ratio of the cells, which were of positive α-naphthyl acetate esterase activity and phagocytic activity, whereas it hardly influenced the naphthol AS-D chloroacetate esterase activity in the cells, as well as 1α, 25(OH)_2D_3 (10nM). In addition, hypericin increased hypodiploid nuclei and caused a nucleosomal ladder. These results indicate that hypericin induced both differentiation toward monocyte/macrophage lineage and apoptosis in HL-60 cells.
- 公益社団法人日本薬学会の論文
- 1999-12-15
著者
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LEE Kyung-Tae
College of Pharmacy, Kyung-Hee University
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Lee Kyung-tae
韓国
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Lee Kyung-tae
College Of Pharmacy Kyung-hee University
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Lee Kyung-tae
Coll. Of Pharmacy Kyung-hee Univerisity
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Park Hee-juhn
韓国
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Park Hee-juhn
Division Of Applied Plant Sciences Sangji University
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Park Hee-juhn
Department Of Botanical Resources Sangi University
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PARK Jae-Hoon
College of Medicine, Kyung-Hee University
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KIM Joo-Il
College of Pharmacy, Kyung-Hee University
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Lee Kyung
College Of Pharmacy Kyung Hee University
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Lee Kyung-won
韓国
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Miyamoto Ken-ichi
Dep. Of Clinical Pharmacy Graduate School Of Natural Sci. And Technol. Kanazawa Univ.
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Jung Jee-chang
College Of Medicine Kyung Hee University
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Park J‐h
Kyung‐hee Univ. Seoul Kor
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RHO Young-Soo
College of Pharmacy Kyung Hee University
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CHANG Seoung-Goo
College of Medicine, Kyung Hee University
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PARK Hee-Joun
Department of Botanical Resources, Sangji University
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MIYAMOTO Ken-ichi
Hospital Pharmacy, School of Medicine Kanazawa University
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Park Hee-joun
Department Of Botanical Resources Sangji University
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Chang Seoung-goo
College Of Medicine Kyung Hee University
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Miyamoto Ken-ichi
Department Of Hospital Pharmacy School Of Medicine Kanazawa University
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Miyaamoto Ken-ichi
Department Of Medical Informatics Graduate School Of Medical Science Kanazawa University
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Miyamoto Ken-ichi
Graduate School Of Natural Science And Technology Kanazawa University
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Miyamoto K
Department Of Hospital Pharmacy School Of Medicine Kanazawa University
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Miyamoto K
Kanazawa Univ. Hospital Ishikawa Jpn
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Park Jae-hoon
College Of Medicine Kyung Hee University
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Kim Joo-il
College Of Pharmacy Kyung-hee University
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