Cytotoxic Components of Bardanae Fructus (Goboshi)
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概要
- 論文の詳細を見る
Bardanae Furctus (Goboshi) extract showed potent in vitro cytotoxicity and in vivo antitumor activity against human hepatoma HepG2 cells and mouse sarcoma 180 cells, respectively. In this study, the cytotoxicities of four fractions and three major components (arctiin, arctigenin, and chlorogenic acid) isolated from Goboshi extract were examined. Arctiin and arctigenin, which were contained in the ethylacetate fraction and n-butanol fraction, respectively, showed stroug cytotoxicity against HepG2 cells, but little toxicity against Chang liver cells. Chlorogenic acid isolated from the water fraction did not affect the viability of these cells. The cytotoxicity of arctigenin against Chang liver cells was markedly potentiated by treatment with a glutathione (GSH) synthesis inhibitor, L-buthionine-(S, R)-sulfoximine (BSO). On the other hand, in HepG2 cells, the cytotoxicity of arctigenin was hardly changed by BSO. The cytotoxicity of arctigenin against HepG2 cells increased in an exposure-time dependent manner. These characteristics of arctigenin were similar to those of Goboshi extract, as previously observed. We therefore conclude that the principal cytotoxic components of Goboshi extract are arctiin and its aglycone arctigenin.
- 公益社団法人日本薬学会の論文
- 1996-11-15
著者
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Nomura Masaaki
北陸大学 薬学部臨床薬理学
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Nomura Masaaki
北陸大学 薬学部合成化学
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Miyamoto K
Department Of Hospital Pharmacy School Of Medicine Kanazawa University:department Of Medicinal Infor
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Nomura Masaaki
Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University
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Nomura Masaaki
Faculty Of Pharmaceutical Sciences Hokuriku University
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MORITANI Shuzo
Department of Nursing, Faculty of Nursing and Welfare, Fukui Prefectural University
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MORITANI Shuzo
Fukui Prefectural University College of Nursing
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MIYAMOTO Ken-ichi
Graduate School of Natural Science and Technology, Kanazawa University
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TAKEDA Yasunori
Tsumura & Co.,
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Miyamoto Ken-ichi
Graduate School Of Natural Science And Technology Kanazawa University
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Morito Satoshi
Department Of Clinical Pharmacy Graduate School Of Natural Science And Technology Kanazawa Universit
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Moritani Shuzo
Department Of Nursing Faculty Of Nursing And Welfare Fukui Prefectural University
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Noguchi Masamichi
Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University
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Miyamoto Ken-ichi
Graduate School Of Natural Sci. And Technol. Kanazawa Univ.
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Nomura Masaaki
Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Hokuriku University
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