Condensed-Purines Syntheses of Tetrahydro-1,4-diazepino[1,2,3-gh]purin-2-one and Hexahydro-1,4-diazocino[1,2,3-gh]purin-2-one

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概要

• 論文の詳細を見る

• 1,4-Pyrimido- (2a), 1,4-diazepino- (2b), and 1,4-diazocino[1,2,3-gh]purine (2c) were designed as selective cAMP-phosphodiesterase 4 (PDE 4) inhibitors. The desired condensed-purines(2b, c) were synthesized by reaction of 7-aminoalkyl-3-propylpurine-2,4-diones (6b, c) with hexamethyldisilazane by intramolecular cyclization via silylation-amination.

• 社団法人日本薬学会の論文
• 1999-09-15

著者

• YAMAMOTO Kenji

  Department of Medical Ecology and Informatics, Research Institute, International Medical Center of J

• Sawanishi Hiroyuki

  Department Of Medicinal Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• Sawanishi H

  Hokuriku Univ. Kanazawa

• Suzuki Hideyo

  Toyama Prefectural Institute For Pharmaceutical Research

• Suzuki H

  Toyama Prefectural Institute For Pharmaceutical Research

• Suzuki H

  Department Of Medicinal Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• SUZUKI Hirokazu

  Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University

• MIYAMOTO Ken-ichi

  Faculty of Pharmaceutical Science

• Yokogawa Koichi

  Department Of Clinical Pharmaceutics Graduate School Of Pharmaceutical Sciences Kanazawa University

• Yokogawa Koichi

  Department Of Hospital Pharmacy Kanazawa University Hospital

• Miyamoto Ken-ichi

  Department Of Hospital Pharmacy School Of Medicine Kanazawa University

• Miyaamoto Ken-ichi

  Department Of Medical Informatics Graduate School Of Medical Science Kanazawa University

• Miyamoto Ken-ichi

  Graduate School Of Natural Science And Technology Kanazawa University

• Sawanishi Hiroyuki

  Faculty Of Pharmaceutical Sciences Hokuriku University

• Suzuki H

  Janssen Pharmaceutical K.k. Shizuoka Jpn

• Suzuki Hirokazu

  Department Of Biomolecular Engineering Graduate School Of Engineering Tohoku University

• Yamamoto K

  Faculty Of Pharmaceutical Sciences Josai University

• Miyamoto K

  Kanazawa Univ. Hospital Ishikawa Jpn

• Sawanishi H

  Department Of Medicinal Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• Miyamoto Ken-ichi

  Faculty Of Industrial Science And Technology Science University Of Tokyo

• Suzuki Hirokazu

  Department Of Applied Chemistry College Of Engineering Chubu University

• Yamamoto Kenji

  Department Of Cardiovascular Surgery Kanagawa Cardiovascular And Respiratory Center

• Suzuki Hirokazu

  Department Of Medicinal Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

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