An Involvement of Granulocyte Medullasin in Phenytoin-Induced Gingival Overgrowth in Rats
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概要
- 論文の詳細を見る
To investigate the relationship between histological changes and distributions of medullasin, a neutrophil elastase-like serine proteinase, in phenytoin-induced gingival overgrowth, we established a rat model of gingival overgrowth. Thirty-two, 20-day-old male Fischer 344 rats were fed a diet containing phenytoin and sacrificed at 1, 2, 4 and 8 weeks. Control rats (n = 40) were fed the same diet, but without the drug and killed at the same weeks as experimental rats (n = 32) and 0 week (n = 8). The mandible specimens were resected and sectioned bucco-lingually between the first and second molars. A marked inflammatory-cell infiltration and elongated rete pegs were seen in the phenytoin-treated group. The extent of the overgrowth assessed by computer image analysis and the density of medullasin-positive cells by immunohistochemistry in the approximal gingiva showed a significant increase in the phenytoin-treated group compared to the control group. A marked infiltration of the positive cells in experimental rats was observed as early as 2 weeks when gingival overgrowth was not fully established. Medullasin-positive cells were mostly neutrophils and partly macrophage-like cells. These findings suggest that medullasin may be involved in mainly host defense and secondarily collagen metabolism in the phenytoin-induced rat model of gingival overgrowth.
- 社団法人 日本薬理学会の論文
- 2002-07-01
著者
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OZAKI Yukio
Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi
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YAMAMOTO Kenji
Department of Medical Ecology and Informatics, Research Institute, International Medical Center of J
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Ozaki Yukio
Department Of Periodontology Nagasaki University School Of Dentistry
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KATO Yuzo
Department of Pharmacology, Nagasaki University Shool of Dentistry
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KUNIMATSU Kazushi
Department of Periodontology, Nagasaki University School of Dentistry
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HARA Yoshitaka
Department of Periodontology, Nagasaki University School of Dentistry
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KATO Ihachi
Department of Periodontology, Nagasaki University School of Dentistry
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AOKI Yosuke
Department of Food and Health Sciences, Jissen Woman's University Faculty of Life Sciences
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Ozaki Yukio
Department Of Cardiology Aichi Medical University
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Kato Yuzo
Department Of Pharmacology Nagasaki University School Of Dentistry
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Kato Ihachi
Department Of Periodontology Nagasaki University School Of Dentistry
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Aoki Yosuke
Department Of Food And Health Sciences Jissen Woman's University Faculty Of Life Sciences
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Aoki Yosuke
Department Of Chemistry Tokyo Metropolitan University
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Hara Yoshitaka
Department Of Periodontology Nagasaki University School Of Dentistry
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Kato Yuzo
Department Of Oral Pathopharmacology Course Of Medical And Dental Sciences Graduate School Of Biomed
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Kunimatsu Kazushi
Department Of Periodontology Nagasaki University School Of Dentistry
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Hara Yoshitaka
Department Of Lowland Farming Hokuriku National Agricultural Experiment Station
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Yamamoto Kenji
Department Of Chemistry Hokuriku University
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Yamamoto Kenji
Department Of Cardiovascular Surgery Kanagawa Cardiovascular And Respiratory Center
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Yamamoto Kenji
Department Of Pharmacology Kyushu University Graduate School Of Dental Sciences
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