Effects of Sphingosine 1-Phosphate, a Naturally Occurring Biologically Active Lysophospholipid, on the Rat Cardiovascular System
スポンサーリンク
概要
- 論文の詳細を見る
Recent studies have indicated that sphingosine 1-phosphate(Sph-1-P)is released into the blood flow from activated platelets upon stimulation to exhibit a wide spectrum of biological functions.The purpose of the present study was to assess the acute cardiovascular effects of circulating Sph-1-P in the in vivo rat model.Intravenous administration of Sph-1-P decreased the heart rate, ventricular contraction and blood pressure, while it hardly affected the atrioventricular and intraventricular conduction.Sph-1-P did not affect the adenylate cyclase activities of the membrane preparations made from the right atrium and left ventricle.These results suggest that functional receptors like lysophospholipid receptor Edg-1, which can inhibit adenylate cyclase via Gi protein, are lacking in the rat heart.Moreover, these observations will provide a clue to better understand the various types of Sph-1-P-related pathophysiological processes.
- 社団法人 日本薬理学会の論文
- 2000-04-01
著者
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OZAKI Yukio
Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi
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矢冨 裕
Department Of Clinical Laboratory The University Of Tokyo Hospital
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Yatomi Yutaka
山梨大学 医学部臨床検査医学
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Yatomi Yutaka
Department Of Pharmacology University Of Yamanashi Faculty Of Medicine
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Yatomi Yutaka
山梨大学 薬理
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矢冨 裕
山梨医科大学臨床検査医学
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矢冨 裕
山梨医科大学 医学部 臨床検査医学講座
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HASHIMOTO Keitaro
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, Universit
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Sugiyama Atsushi
Department of Pharmacology, School of Medicine, Toho University, Japan
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Yatomi Yutaka
Department Of Clinical Laboratory Medicine Graduate School Of Medicine The University Of Tokyo
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AYE Nu
Department of Pharmacology, Yamanashi Medical University
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Ozaki Yukio
Department Of Cardiology Aichi Medical University
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Ozaki Yukio
Department Of Laboratory Medicine Yamanashi Medical University
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Yatomi Yutaka
Department Of Laboratory Medicine Graduate School Of Medicine University Of Tokyo
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Aye Nu
Department Of Pharmacology Yamanashi Medical University
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Sugiyama Atsushi
Department Of Pharmacology Yamanashi Medical University
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Sugiyama Atsushi
Department Of Pharmacology. University Of Yamanashi Yamanashi Research Center Of Cliniacl Pharmacolo
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Sugiyama Atsushi
Department Of Chemistry College Of Science Rikkyo University
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Sugiyama Atsushi
Department Of Pharmacology School Of Medicine Toho University
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Yatomi Yutaka
Department Of Clinical Laboratory Graduate School Of Medicine The University Of Tokyo
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HASHIMOTO Keitaro
Department of Phamacology, Yamanashi Medical University
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Yatomi Yutaka
Department Clinical Laboratory Medicine, Graduate School of Medicine and Faculty of Medicine, University of Tokyo
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Sugiyama Atsushi
Department of Biotechnology, Faculty of Engineering, Kansai University
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YATOMI Yutaka
Department of Clinical and Laboratory Medicine, Yamanashi Medical College
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