Comparison of the Electropharmacological Effects of Verapamil and Propranolol in the Halothane-Anesthetized In Vivo Canine Model Under Monophasic Action Potential Monitoring
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概要
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The caediovascular profile of verapamil was assessed in the halothane-anesthetized canine model and compared with that of propranolol. Verapamil was infused at the rates of 1, 3 and 10μg・kg^<-1>・min^<-1> (n=6), whereas propranolol was administered at a fixed rate of 10μg・kg^<-1>・min^<-1> (n=6). Each infusion was performed over 30 min, and the parameters were assessed for 20-30 min after the start of each infusion. Verapamil in a dose of 10μg・kg^<-1>・min^<-1> significantly suppressed atrio-ventricular (AV) node conduction and slightly decreased the mean blood pressure, but no significant change was detected in the left ventricular end-diastolic pressure, maximum upstroke velocity of the left ventricular pressure, sinus automaticity, double product, cardiac output, intraventricular conduction, and ventricular repolarization phase and refractoriness. Propranolol suppressed AV node conduction to an extent similar to that of verapamil, but it also inhibited intraventricular conduction, sinus automaticity and ventricular contraction, increased the ventricular refractoriness, and decreased the double product and cardiac output, without any significant change in the other variables measured. These results suggest that verapamil can selectively affect the AV node, and that the greater part of the suppressive action of propranolol on the multiple cardiovascular performance is through a β-blocking action and direct membrane effect, although the halothane inhalation itself might have modified each of the drug's effects. The abbreviation of the relative refractory period of the ventricle by propranolo may show its potential utility for re-entry type ventricular tachycardia.
- 社団法人日本循環器学会の論文
- 2000-09-20
著者
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HASHIMOTO Keitaro
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, Universit
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Sugiyama Atsushi
Department of Pharmacology, School of Medicine, Toho University, Japan
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Satoh Y
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Shiina Hiroyuki
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Shimada Hideaki
Department Of Gastroenterological Surgery Chiba Cancer Center
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Shimada H
Kumamoto Univ. Kumamoto
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Shimada Hideaki
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Science
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TAKAHARA Akira
Pharmaceutical Research Laboratories, Ajinomoto Co., Inc.
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Shiina Hiroyuki
Second Department of Internal Medicine, Shinshu University, School of Medicine
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Satoh Yoshioki
Department of Pharmacology, Yamanashi Medical University
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Satoh Yoshioki
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Takahara Akira
Pharmaceutical Research Laboratories Ajinomoto Co. Inc.
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Sugiyama Atsushi
Department Of Pharmacology Yamanashi Medical University
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Sashiyama Hiroshi
千葉大学 医学研究院先端応用外科学
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Shiina Hiroyuki
Second Department Of Internal Medicine Shinshu University School Of Medicine
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Sugiyama Atsushi
Department Of Pharmacology. University Of Yamanashi Yamanashi Research Center Of Cliniacl Pharmacolo
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Sugiyama Atsushi
Department Of Chemistry College Of Science Rikkyo University
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Aikawa Tokiko
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Sugiyama Atsushi
Department Of Pharmacology School Of Medicine Toho University
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HASHIMOTO Keitaro
Department of Phamacology, Yamanashi Medical University
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Sugiyama Atsushi
Department of Biotechnology, Faculty of Engineering, Kansai University
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