DEVELOPMENT OF TELEMETRY SYSTEM IN THE COMMON MARMOSET : CARDIOVASCULAR EFFECTS OF ASTEMIZOLE AND NICARDIPINE

概要

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The purpose of this study was to evaluate a telemetry system for examining the cardio-vascular system in the conscious common marmoset. Parameters obtained were blood pressure, heart rate, respiratory rate, ECG, body temperature and locomotor activity, and these were continuously recorded on a data recorder via the telemetry system and then processed by a computerized system. Diurnal rhythms of blood pressure, heart rate, body temperature and locomotor activity were observed in this system. We studied the effects of astemizole (antihistamine) and nicardipine (Ca^<2+> channel blocker) on cardiovascular parameters. Astemizole at 30 mg/kg (po) and at 1 to 3 mg/kg (iv), prolonged QT interval and induced ventricular extrasystole. Torsades de pointes occurred in one of three cases at 3 mg/kg (iv) and 30 mg/kg (po), while it did not affect the blood pressure, respiratory rate and body temperature. Nicardipine at 30 mg/kg (po) caused sustained hypotension and tachycardia. These results demonstrate the usefulness of the telemetry system using the common marmoset for evaluating the cardiovascular effects of drugs under physiological conditions.
日本トキシコロジー学会の論文
2002-05-17