Cardiovascular Effects of Orally Administered HNS-32, an Originally Synthesized Azulene-1-carboxamidine Derivative, Assessed in the In Vivo Rat Model
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概要
- 論文の詳細を見る
HNS-32, an azulene-1-carboxamidine derivative, is an originally synthesized antiarrhythmic compound. Its cardiovascular effects after oral administration (1 – 10 mg/kg) were assessed using the pentobarbital-anesthetized in vivo rat model in comparison with those of verapamil (3 mg/kg, p.o.). Verapamil decreased the heart rate and mean blood pressure and prolonged the PR interval without changing the QRS width (n = 6). Similar results were observed for HNS-32 except that the QRS width was prolonged by the highest dose and the effects occurred slowly and lasted longer. These results suggest that HNS-32 is an orally active slowly-acting calcium plus sodium channel blocker.
- 社団法人 日本薬理学会の論文
- 2002-07-01
著者
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HASHIMOTO Keitaro
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, Universit
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Sugiyama Atsushi
Department of Pharmacology, School of Medicine, Toho University, Japan
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SAITOH MASAKI
Department of Internal Medicine, School of Medicine, Teikyo University
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Saitoh Masaki
Department Of Pharmacology Yamanashi Medical University
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Nakazawa Tomoo
Department Of Chemistry Yamanashi Medical University
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Nakazawa Tomoo
Department Of Chemistry Yamanashi Medical College
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Sugiyama Atsushi
Department Of Pharmacology Yamanashi Medical University
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Hashimoto Keitaro
Department Of Pharmacology Yamanashi Medical University
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Sugiyama Atsushi
Department Of Chemistry College Of Science Rikkyo University
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