Comparison of the In Vivo Electrophysiological and Proarrhythmic Effects of Amiodarone With Those of a Selective Class III Drug, Sematilide, Using a Canine Chronic Atrioventricular Block Model

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概要

• 論文の詳細を見る

• Amiodarone effectively blocks both the sodium and calcium channels and β-adrenoceptors, in addition to blocking several potassium currents including I_<Kr>, I_<Ks>, I_<to>, I_<Kl>, I_<KACh> and I_<KNa>. The incidence of clinical torsade de pointes (TdP) associated with amiodarone has been reported to be low and the present study compared the proarrhythmic potential of amiodarone with that of a selective I_<Kr> channel blocker, sematilide, using a canine chronic atrioventrucular block model. Amiodarone or sematilide (3 and 30 mg/kg; n=4 for each group) was administered orally without anesthesia under continuous ECG monitoring. Both drugs prolonged the QT interval, although the onset was faster for sematilide. The high dose of sematilide induced TdP in 3 of 4 animals, which caused their death, but neither the low dose of sematilide nor the 2 dosages of amiodarone induced lethal ventricular arrhythmias. These results suggest that I_<Kr> channel inhibition by amiodarone with its additional ion channel blocking action may contribute to the prevention of TdP.

• 社団法人日本循環器学会の論文
• 2002-07-20

著者

• Ishida Yuko

  Department of Forensic Medicine, Wakayama Medical University

• Kugiyama Kiyotaka

  Second Department of Internal Medicine, Yamanashi University School of Medicine

• YOSHIDA Hiroshi

  Second Department of Medicine, Kurume University School of Medicine

• HASHIMOTO Keitaro

  Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, Universit

• Sugiyama Atsushi

  Department of Pharmacology, School of Medicine, Toho University, Japan

• Satoh Y

  Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University

• Satoh Yoshioki

  Department of Pharmacology, Yamanashi Medical University

• Kugiyama Kiyotaka

  Second Department Of Internal Medicine Interdisciplinary Graduate School Of Medicine And Engineering

• Kugiyama Kiyotaka

  Second Department Of Internal Medicine Yamanashi Medical University

• Satoh Yoshioki

  Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University

• Ishida Yuko

  Department Of Pharmacology Yamanashi Medical University

• Ishida Yuko

  Department Of Forensic Medicine Wakayama Medical University

• Sugiyama Atsushi

  Department Of Pharmacology Yamanashi Medical University

• Sugiyama A

  Department Of Pharmacology Yamanashi Medical University

• Yoneyama Masahiko

  Department of Pharmacology, Yamanashi Medical University

• Yoneyama Masahiko

  Department Of Pharmacology Yamanashi Medical University

• Hashimoto Keitaro

  Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University

• Hashimoto Keitaro

  Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University

• Sugiyama Atsushi

  Department Of Pharmacology. University Of Yamanashi Yamanashi Research Center Of Cliniacl Pharmacolo

• Sugiyama Atsushi

  Department Of Chemistry College Of Science Rikkyo University

• Sugiyama Atsushi

  Department Of Pharmacology School Of Medicine Toho University

• Yoshida Hiroshi

  Department Of Pharmacology Yamanashi Medical University

• Yoshida Hiroshi

  Second Department Of Internal Medcine University Of Yamanashi

• HASHIMOTO Keitaro

  Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi

• HASHIMOTO Keitaro

  Department of Phamacology, Yamanashi Medical University

• Sugiyama Atsushi

  Department of Biotechnology, Faculty of Engineering, Kansai University

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