Relationship Between Phosphodiesterase Inhibition Induced by Several Kampo Medicines and Smooth Muscle Relaxation of Gastrointestinal Tract Tissues of Rats
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概要
- 論文の詳細を見る
Given a lack of information, we assessed the effects of Kampo medicines: Dai-saiko-to, Tsu-do-san, San’o-shashin-to, and Sairei-to, which have been used for various gastrointestinal diseases, on the phosphodiesterase activity and smooth muscle tone of the gastrointestinal tract. Clinically relevant concentrations of each Kampo extract (0.1 – 1 mg/ml) decreased the phosphodiesterase activity as well as smooth muscle tone. The extent of phosphodiesterase inhibition as well as smooth muscle relaxation by these Kampo extracts was prominent for the lower gastrointestinal tract. Also, there was a good correlation between the extents of drug-induced phosphodiesterase inhibition and smooth muscle relaxation, indicating the presence of their causal link. These results may partially provide the basis for understanding the mechanism of the clinical utility of Kampo extracts in gastrointestinal tract diseases.
- 社団法人 日本薬理学会の論文
- 2003-09-01
著者
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HASHIMOTO Keitaro
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, Universit
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Sugiyama Atsushi
Department of Pharmacology, School of Medicine, Toho University, Japan
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Satoh Y
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Takahara Akira
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Takahara Akira
Department Of Internal Medicine National Kawatana Hospital
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Sugiyama Atsushi
Department Of Pharmacology Yamanashi Medical University
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Sugiyama A
Department Of Pharmacology Yamanashi Medical University
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NAGASAWA Yoshinobu
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, Universit
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SAEGUSA Yoshiki
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, Universit
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Nagasawa Yoshinobu
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Nagasawa Yoshinobu
Department Of Human Science And Fundamentals Of Nursing
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Sugiyama Atsushi
Department Of Pharmacology. University Of Yamanashi Yamanashi Research Center Of Cliniacl Pharmacolo
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Sugiyama Atsushi
Department Of Chemistry College Of Science Rikkyo University
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Aikawa Tokiko
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Sugiyama Atsushi
Department Of Pharmacology School Of Medicine Toho University
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HASHIMOTO Keitaro
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
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HASHIMOTO Keitaro
Department of Phamacology, Yamanashi Medical University
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Sugiyama Atsushi
Department of Biotechnology, Faculty of Engineering, Kansai University
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Takahara Akira
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Toho University
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