DECREASE OF PLASMA SULFUR AMINO ACIDS IN ESSENTIAL HYPERTENSION
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概要
- 論文の詳細を見る
In order to evaluate the correlation between sulfur amino acids (derived mainly form animal protein in the diet) and blood pressure, free amino acids, including sulfur amino acids such as taurine and methionine, were determined in the plasma and cerebrospinal fluid (CSF) of twelve normotensive subjects and twelve patients with essential hypertension under nutritional control after at least 10 days of standard hospital diet (total calorie and protein content: 2100-2300 Cal per day and 78-83g per day, respectively). The results obtained were as follows: plasma taurine, serine, methionine and threonine were significantly lower in patients with essential hypertension than in normotensive patients. The levels of plasma taurine, serine, methionine and total sulfur amino acids in individuals correlated inversely to systolic blood pressure. No difference was observed in the CSF levels of free amino acids in normotensive and hypertensive patients. As taurine, methionine and serine are involved in the metabolism of sulfur amino acids, these observations support the view that the decrease in plasma sulfur amino acids may be a factor contributing to elevated blood pressure.
- 社団法人日本循環器学会の論文
- 1985-12-20
著者
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Takahara Akira
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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OGAWA MASASHI
Department of Pharmacology and *Neurosurgery, School of Medicine, Nagasaki University
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Takahara Akira
Department Of Internal Medicine National Kawatana Hospital
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Ogawa Masashi
Department Of Lnternal Medicine National Kawatana Hospital
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ISHIJIMA MITSUAKI
Department of Internal Medicine, National Kawatana Hospital
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TAZAKI SHINSUKE
Department of Internal Medicine, National Kawatana Hospital
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Ishijima Mitsuaki
Department Of Internal Medicine National Kawatana Hospital
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Ogawa Masashi
Department Of Internal Medicine National Kawatana Hospital
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Tazaki Shinsuke
Department Of Internal Medicine National Kawatana Hospital
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Takahara Akira
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Toho University
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