H2 Receptor-Mediated Positive Inotropic Effect of Histamine in Neonatal Guinea-Pig Left Atria
スポンサーリンク
概要
- 論文の詳細を見る
The receptor type mediating the positive inotropic effect of histamine was examined in left atria from neonatal guinea pigs. The positive inotropic effect of histamine, as well as its action potential prolonging effect, was antagonized by ranitidine, but not by chlorpheniramine or thiperamide. The positive inotropic effect was enhanced by isobutylmethylxantine. Receptor binding studies revealed the presence of both H1 and H2 receptor types. These results suggest that the positive inotropic effect of histamine in the neonatal guinea-pig atrium is mediated by H2 receptors.
- 公益社団法人 日本薬学会の論文
著者
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Koike Katsuo
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Namekata Iyuki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Tanaka Hikaru
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Chino Daisuke
Department Of Pharmacology And Pharmacotherapy School Of Medicinal Pharmaceutical Sciences Nihon Pha
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Takahara Akira
Department Of Internal Medicine National Kawatana Hospital
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Tanaka Yoshio
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Kato Yoshimitsu
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Agata Naoki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Tanaka Hikaru
Department Of Internal Medicine Sasebo Senjyu Hospital
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Namekata Iyuki
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Tanaka Yoshio
Department Of Applied Chemistry Faculty Of Engineering Yokohama National University
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Tanaka Hikaru
Department Of Internal Medicine Hirosaki Municipal Hospital
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Namekata Iyuki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Toho University
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Tanaka Yoshio
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Kato Yoshimitsu
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Tanaka Hikaru
Department of Endocrinology and Metabolism, Hirosaki University
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Koike Katsuo
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Takahara Akira
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Toho University
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Chino Daisuke
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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