Optical Bioimaging : From Living Tissue to a Single Molecule : Atrio-Ventricular Difference in Myocardial Excitation-Contraction Coupling : Sequential Versus Simultaneous Activation of SR Ca^<2+> Release Units
スポンサーリンク
概要
- 論文の詳細を見る
Rapid-scanning cofocal microscopy has been applied to the analysis of early phase Ca2+ transients in ventricular and atrial cardiomyocytes. On electrical stimulation of ventricular myocytes, Ca2+ concentration begins to rise earliest at the Z-line level and becames uniform throughout the cytoplasm within about 10 ms after the onset of the action potential; transsarcolemmal Ca2+ influx triggers Ca2+ release from release sites on the junctional sarcoplasmic reticulum (SR) coupled to T-tubules at the Z-line throughout the cytoplasm. In atrial myocytes lacking the T-tubular network, transsarcolemmal Ca2+ influx during an action potential triggers SR Ca2+ release only at subsarcolemmal region. SR Ca2+ release then spreads towards the central region of the cell thourgh a propagated Ca2+-induced-Ca2+ release mechanism. The atrio-ventricular difference in excitation-contraction coupling mechanisms underlies some of the atrio-ventricular difference in response to physiological and pharmacological stimuli.
- 社団法人 日本薬理学会の論文
- 2003-11-01
著者
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KAWANISHI Toru
Division of Biological Chemistry and Biologicals, National Institute of Health Sciences
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TANAKA Hikaru
Department of Pharmacology, Toho University School of
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SHIGENOBU Koki
Department of Pharmacology, Toho University School of
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Tanaka Hikaru
Dep. Of Pharmacology Toho Univ. Fac. Of Pharmaceutical Sciences Jpn
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Kawanishi T
Division Of Drugs National Institute Of Health Science
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Kawanishi Toru
Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences
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Shigenobu K
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Shigenobu K
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Shigenobu Koki
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Tanaka Hikaru
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Shigenobu Koki
Toho University School Of Pharmaceutical Sciences
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Kawanishi Toru
Division Of Drugs National Institute Of Health Science
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Kawanishi Toru
国立医薬品食品衛生研究所
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Tanaka Hikaru
Department Of Internal Medicine Sasebo Senjyu Hospital
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Tanaka Hikaru
Department Of Internal Medicine Hirosaki Municipal Hospital
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