The Relationship between Spontaneous Calcium Oscillations and Cell Proliferation in Cultured Smooth Muscle Cells.
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概要
- 論文の詳細を見る
The relationship between spontaneous Ca<SUP>2+</SUP> oscillations and cell proliferation was investigated in cultured longitudinal muscle cells from guinea pig ileum. BAPTA, caffeine, thapsigargine and La<SUP>3+</SUP> suppressed the spontaneous Ca<SUP>2+</SUP> oscillations and the DNA synthesis at 5.0 mM, 10.0 mM, 15.62 nM and 0.5 mM, respectively, whereas verapamil, nicardipine and ryanodine did not suppress either. However, BAPTA and La<SUP>3+</SUP> did not inhibit the DNA synthesis at 1.25 mM and 0.13 mM, but did suppress the Ca<SUP>2+</SUP> oscillations even at 1.0 mM and 0.1 mM, respectively. These results show that the spontaneous Ca<SUP>2+</SUP> oscillations are not prerequisite for the cell proliferation.
- 公益社団法人 日本薬理学会の論文
著者
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Kawanishi Toru
Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences
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TOYODA Kazuhiro
Division of Pathology
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Takahashi Michihito
Division Of Pathology National Institute Of Health Sciences
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Ohata Hisayuki
Department Of Pharmacology School Of Pharmaceutical Sciences Showa University
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Momose Kazutaka
Department Of Phamacology School Of Pharmaceutical Sciences Showa University
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Hayashi Yuzo
Division Of Pathology National Institute Of Hygienic Sciences
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Kawanishi Megumi
Department of Pharmacology, School of Pharmaceutical Sciences, Showa University
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Hayashi Yuzo
Division of Pathology, Biological Safety Research Center, National Institute of Health Sciences
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