Inositol 1,4,5-Trisphosphate-Induced Contraction in Skinned Single Smooth Muscle Cells from Guinea-Pig Taenia Coli
スポンサーリンク
概要
- 論文の詳細を見る
Inositol 1,4,5-trisphosphate (IP_3) caused a contraction in skinned single smooh muscle cells from the guinea-pig taenia coli. The contractile response to IP_3 was rapid (half time < 5s), concentration-dependent (0.01-10μM, EC_<50> ; 0.1μM) and also depended on the concentration of Ca^<2+>during preloading. IP_3 induced a rapid ^<45>Ca^<2+> release from the skinned single cells which were preloaded with 10^<-6>M Ca^<2+>. The contractile response caused by IP_3 was not enhanced by simultaneous application of caffeine (25mM). The inhibitory effect of procaine on IP_3-induced contraction was less than that on caffeine-induced contraction. These results suggest that IP_3 also plays an important role in the contractile response in smooth muscle cells from guinea-pig taenia coli and that the mechanism of Ca^<2+> release from intracellular storage sites by IP_3 is different from that by caffeine.
- 公益社団法人日本薬学会の論文
著者
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MAEDA Takashi
Department of Bioscience and Biotechnology, Faculty of Engineering, Graduate School of Natural Scien
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OHATA Hisayuki
Department of Pharmacology, School of Pharmaceutical Sciences, Showa University
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MOMOSE Kazutaka
Department of Pharmacology, School of Pharmaceutical Sciences, Showa University
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Maeda T
Department Of Pharmacology School Of Pharmaceutical Sciences Showa University
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Ohata H
Department Of Pharmacology School Of Pharmaceutical Sciences Showa University
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Ohata Hisayuki
Department Of Pharmacology School Of Pharmaceutical Sciences Showa University
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Momose K
Department Of Pharmacology School Of Pharmaceutical Sciences Showa University
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Momose Kazutaka
Department Of Phamacology School Of Pharmaceutical Sciences Showa University
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Maeda Takashi
Department Of Agricultural Engineering Faculty Of Agriculture Hokkaido University
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